Trial reportJournal of hypertension2017
Repetitive exposure to shortened sleep leads to blunted sleep-associated blood pressure dipping.
Trial report in Journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 68 citations in OpenAlex.
- Acute night shift work is associated with increased blood pressure and reduced sleep duration in healthy adults.Physiological reports · 2025Trial
- Effects of Experimental Sleep Restriction on Ambulatory and Sleep Blood Pressure in Healthy Young Adults: A Randomized Crossover Study.Hypertension (Dallas, Tex. : 1979) · 2021Trial
- Mild sleep restriction increases 24-hour ambulatory blood pressure in premenopausal women with no indication of mediation by psychological effects.American heart journal · 2020Trial
- Fluctuations in Sleep Duration and Timing and Cardiometabolic Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Is sleep a mechanistic factor in the blood pressure lowering effects of low-dose aspirin taken at bedtime? A pilot study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Influence of sleep and cardiovascular health on cognitive trajectories in older adults.Neurobiology of aging · 2025Observational
- Association of physical activity, sedentary time, and sleep with maternal vascular function in women with a history of preeclampsia.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Blunted Blood Pressure Dipping During Night Shift Work: Does It Matter? Can We Intervene?American journal of industrial medicine · 2025Article
- Short Sleep Duration and Hypertension: A Double Hit for the Brain.Journal of the American Heart Association · 2024Article
- The association between sleep duration and muscle sympathetic nerve activity.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
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- Beyond the symptom: the biology of fatigue.Sleep · 2023Review
- Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report.Hypertension (Dallas, Tex. : 1979) · 2023Review
- The Relationship between Sleep Duration and Metabolic Syndrome Severity Scores in Emerging Adults.Nutrients · 2023Article
- Wildfire-related smoke inhalation worsens cardiovascular risk in sleep disrupted rats.Frontiers in environmental health · 2023Article
- Sleep, testosterone and cortisol balance, and ageing men.Reviews in endocrine & metabolic disorders · 2022Review
- The Oscillometric Pulse Wave Analysis Is Useful in Evaluating the Arterial Stiffness of Obese Children with Relevant Cardiometabolic Risks.Journal of clinical medicine · 2022Article
- The Association Between Habitual Sleep Duration and Blood Pressure Control in United States (US) Adults with Hypertension.Integrated blood pressure control · 2022Article
- Association between Sleep Duration and Hypertension among Adults in Southwest China.Global heart · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBlood pressure (BP) dips at night during sleep in healthy individuals but in disturbed sleep, dipping is blunted. However, the impact of chronic insufficient sleep duration, with limited intermittent recovery sleep, on BP dipping is not known. The objective of this study was to examine, in a controlled experimental model, the influence of chronic sleep restriction on BP patterns at night and during the day.
methodIn a highly controlled 22-day in-hospital protocol, 45 healthy participants (age 32 ± 2 years; BMI 24 ± 1 kg/m; 22 men and 23 women) were randomly assigned to one of two conditions: repeated sleep restriction (4 h of sleep/night from 0300 to 0700 h for three nights followed by recovery sleep of 8 h, repeated four times in succession) or a sleep control group (8 h/night from 2300 to 0700 h).
resultsBeat-to-beat BP and polysomnography were recorded and revealed that sleep-associated DBP dipping was significantly blunted during all four blocks of sleep restriction (P = 0.002). Further, DBP was significantly increased for the whole day during the first, second, and fourth block of sleep restriction (all P < 0.01), and SBP was significantly increased for the whole day during the first block of sleep restriction.
conclusionRepeated exposure to significantly shortened sleep blunts sleep-associated BP dipping, despite intermittent catch-up sleep. Individuals frequently experiencing insufficient sleep may be at increased risk for hypertension due to repetitive blunting of sleep-associated BP dipping, and resultant elevations in average circadian BP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.