ArticleScientific reports2017
Allometric scaling in-vitro.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Passage-Dependent Size Distributions of Human-Derived Cells: Implications for Metabolic Assays.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Patient-Specific Size and Age Scaling in a Zero Dimensional Cardiovascular Model.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Evolvoid: a genetic algorithm for shaping optimal cellular constructs.Journal of biological engineering · 2026Article
- Effects of size scaling on cellular dynamics and tissue patterning in tooth root organoids.Frontiers in bioengineering and biotechnology · 2026Article
- Development of an Easy-To-Use Microfluidic System to Assess Dynamic Exposure to Mycotoxins in 3D Culture Models: Evaluation of Ochratoxin A and Patulin Cytotoxicity.Foods (Basel, Switzerland) · 2024Article
- Size-related variability of oxygen consumption rates in individual human hepatic cells.Lab on a chip · 2024Article
- Development of a novel high-throughput culture system for hypoxic 3D hydrogel cell culture.Scientific reports · 2024Article
- Characterizing and Engineering Biomimetic Materials for Viscoelastic Mechanotransduction Studies.Tissue engineering. Part B, Reviews · 2022Review
- Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics.Open biology · 2022Review
- Application of modified Michaelis - Menten equations for determination of enzyme inducing and inhibiting drugs.BMC pharmacology & toxicology · 2021Article
- Scaling of joint mass and metabolism fluctuations in in silico cell-laden spheroids.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Patient-Specific Organoid and Organ-on-a-Chip: 3D Cell-Culture Meets 3D Printing and Numerical Simulation.Advanced biology · 2021Review
- Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption.Bioengineering (Basel, Switzerland) · 2020Review
- Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy.PLoS computational biology · 2020Article
- Generalized size scaling of metabolic rates based on single-cell measurements with freshwater phytoplankton.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Allometric Scaling of physiologically-relevant organoids.Scientific reports · 2019Article
- An elucidation of over a century old enigma in genetics-Heterosis.PLoS biology · 2019Article
- Recent Advances in Body-on-a-Chip Systems.Analytical chemistry · 2019Review
- Experimental and Computational Methods for the Study of Cerebral Organoids: A Review.Frontiers in neuroscience · 2019Review
- Oxygen Consumption Characteristics in 3D Constructs Depend on Cell Density.Frontiers in bioengineering and biotechnology · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
About two decades ago, West and coworkers established a model which predicts that metabolic rate follows a three quarter power relationship with the mass of an organism, based on the premise that tissues are supplied nutrients through a fractal distribution network. Quarter power scaling is widely considered a universal law of biology and it is generally accepted that were in-vitro cultures to obey allometric metabolic scaling, they would have more predictive potential and could, for instance, provide a viable substitute for animals in research. This paper outlines a theoretical and computational framework for establishing quarter power scaling in three-dimensional spherical constructs in-vitro, starting where fractal distribution ends. Allometric scaling in non-vascular spherical tissue constructs was assessed using models of Michaelis Menten oxygen consumption and diffusion. The models demonstrate that physiological scaling is maintained when about 5 to 60% of the construct is exposed to oxygen concentrations less than the Michaelis Menten constant, with a significant concentration gradient in the sphere. The results have important implications for the design of downscaled in-vitro systems with physiological relevance.
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