ArticleScientific reports2017
Dynamic hub load predicts cognitive decline after resective neurosurgery.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Cognitive outcomes after multimodal treatment in adult glioma patients: A meta-analysis.Neuro-oncology · 2023Pooled it
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- Presurgical structural connectivity predicts postsurgical cognitive impairment in glioma patients.Brain communications · 2025Article
- Deep-learning-optimized microstate network analysis for early Parkinson's disease with mild cognitive impairment.Cognitive neurodynamics · 2024Article
- Symptom networks in glioma patients: understanding the multidimensionality of symptoms and quality of life.Journal of cancer survivorship : research and practice · 2024Article
- Brain tumor-related epilepsy: an overview on neuropsychological, behavioral, and quality of life issues and assessment methodology.Frontiers in neurology · 2024Review
- The longitudinal relation between executive functioning and multilayer network topology in glioma patients.Brain imaging and behavior · 2023Article
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- Mixtures of large-scale dynamic functional brain network modes.NeuroImage · 2022Article
- Cellular Substrates of Functional Network Integration and Memory in Temporal Lobe Epilepsy.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Testing covariance models for MEG source reconstruction of hippocampal activity.Scientific reports · 2021Article
- Cortical electrophysiological evidence for individual-specific temporal organization of brain functional networks.Human brain mapping · 2020Article
- Cognitive functioning in glioma patients is related to functional connectivity measures of the non-tumoural hemisphere.The European journal of neuroscience · 2019Article
- Uncovering Dynamic Brain Reconfiguration in MEG Working MemoryBrain sciences · 2019Article
- Understanding cognitive functioning in glioma patients: The relevance of IDH-mutation status and functional connectivity.Brain and behavior · 2019Article
- How Sensitive Are Conventional MEG Functional Connectivity Metrics With Sliding Windows to Detect Genuine Fluctuations in Dynamic Functional Connectivity?Frontiers in neuroscience · 2019Article
- Oscillatory brain activity associates with neuroligin-3 expression and predicts progression free survival in patients with diffuse glioma.Journal of neuro-oncology · 2018Article
- Changes in functional connectivity are associated with functional independence in the early postoperative period following awake surgical resection of language-eloquent glioma.Neuro-oncology advancesArticle
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resective neurosurgery carries the risk of postoperative cognitive deterioration. The concept of 'hub (over)load', caused by (over)use of the most important brain regions, has been theoretically postulated in relation to symptomatology and neurological disease course, but lacks experimental confirmation. We investigated functional hub load and postsurgical cognitive deterioration in patients undergoing lesion resection. Patients (n = 28) underwent resting-state magnetoencephalography and neuropsychological assessments preoperatively and 1-year after lesion resection. We calculated stationary hub load score (SHub) indicating to what extent brain regions linked different subsystems; high SHub indicates larger processing pressure on hub regions. Dynamic hub load score (DHub) assessed its variability over time; low values, particularly in combination with high SHub values, indicate increased load, because of consistently high usage of hub regions. Hypothetically, increased SHub and decreased DHub relate to hub overload and thus poorer/deteriorating cognition. Between time points, deteriorating verbal memory performance correlated with decreasing upper alpha DHub. Moreover, preoperatively low DHub values accurately predicted declining verbal memory performance. In summary, dynamic hub load relates to cognitive functioning in patients undergoing lesion resection: postoperative cognitive decline can be tracked and even predicted using dynamic hub load, suggesting it may be used as a prognostic marker for tailored treatment planning.
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