ArticleScientific reports2017
DNA methylation governs the dynamic regulation of inflammation by apoptotic cells during efferocytosis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Apoptotic metabolites synthesize and inherit uniqueBioactive materials · 2026Article
- Construction of a prognostic model based on efferocytosis for predicting survival and immunotherapy efficacy in cervical cancer.Translational cancer research · 2025Article
- Review
- ATP functions as a primary alarmin in allergen-induced type 2 immunity.American journal of physiology. Cell physiology · 2023Review
- MicroRNA-181c-5p modulates phagocytosis efficiency in bone marrow-derived macrophages.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- DNA Methylation of T Lymphocytes as a Therapeutic Target: Implications for Rheumatoid Arthritis Etiology.Frontiers in immunology · 2022Review
- The impact of age-related hypomethylated DNA on immune signaling upon cellular demise.Trends in immunology · 2021Article
- Toll-Like Receptor as a Potential Biomarker in Renal Diseases.International journal of molecular sciences · 2020Review
- Treg-inducing capacity of genomic DNA ofAllergy and asthma proceedings · 2020Article
- DNA methylation changes on immune cells in Systemic Lupus Erythematosus.Autoimmunity · 2020Review
- Toll-like receptor 9 negatively related to clinical outcome of AML patients.Journal of the Egyptian National Cancer Institute · 2020Article
- Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis.Frontiers in endocrinology · 2020Review
- Epigenetic Regulation Mediated by Methylation in the Pathogenesis and Precision Medicine of Rheumatoid Arthritis.Frontiers in genetics · 2020Review
- A New Vision of IgA Nephropathy: The Missing Link.International journal of molecular sciences · 2019Review
- Article
- Harnessing Apoptotic Cell Clearance to Treat Autoimmune Arthritis.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Efficient clearance of apoptotic cells (AC) is pivotal in preventing autoimmunity and is a potent immunosuppressive stimulus. However, activation of cells prior to apoptosis abolishes their immunoregulatory properties. Here we show using the antigen-induced model of arthritis that the degree of DNA methylation within AC confers their immunomodulatory plasticity. DNA isolated from resting and activated AC mimicked their respective immune effects. Demethylation of DNA abrogated the protective effect of AC whereas remethylation of AC DNA reversed the effects of activation and restored the ability to inhibit inflammation. Disease suppression or lack thereof was associated with TGFβ and IL-6 production respectively. Apoptotic CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.