Evidence map›Paper›PMID 28169326›Full record

ArticleScientific reports2017

Novel peptides for deciphering structural and signalling functions of E-cadherin in mouse embryonic stem cells.

Joe M Segal, Christopher M Ward

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Overriding native cell coordination enhances external programming of collective cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joe M SegalStem Cell Research Group, The University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, United Kingdom.
Christopher M WardStem Cell Research Group, The University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, United Kingdom.
University of Manchester · GB

Funding

Biotechnology and Biological Sciences Research Council BB/K020277/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C013104/1
6 · The paper itself

Abstract

We have previously shown that E-cadherin regulates the naive pluripotent state of mouse embryonic stem cells (mESCs) by enabling LIF-dependent STAT3 phosphorylation, with E-cadherin null mESCs exhibiting over 3000 gene transcript alterations and a switch to Activin/Nodal-dependent pluripotency. However, elucidation of the exact mechanisms associated with E-cadherin function in mESCs is compounded by the difficulty in delineating the structural and signalling functions of this protein. Here we show that mESCs treated with the E-cadherin neutralising antibody DECMA-1 or the E-cadherin binding peptide H-SWELYYPLRANL-NH

Indexed as

AnimalsCadherinsCell CommunicationCell SurvivalGene ExpressionKruppel-Like Factor 4MiceMouse Embryonic Stem CellsNanog Homeobox ProteinPeptidesPhosphorylationPluripotent Stem CellsSignal TransductionSTAT3 Transcription FactorStructure-Activity RelationshipTranscription, GeneticCadherinsKlf4 protein, mouseKruppel-Like Factor 4Nanog Homeobox ProteinNanog protein, mousePeptidesSTAT3 Transcription Factor

Identifiers

PMID28169326
PMCPMC5294416
OpenAlexW2582937105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.