Evidence map›Paper›PMID 28169284›Full record

ArticleThe American journal of gastroenterology2017

Long-Term Glycemic Control in Adult Patients Undergoing Remote vs. Local Total Pancreatectomy With Islet Autotransplantation.

Samuel J Kesseli, Matthew Wagar, Min K Jung, Kerrington D Smith, Yu Kuei Lin, R Matthew Walsh, Betul Hatipoglu, Martin L Freeman, Timothy L Pruett, Gregory J Beilman and 7 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Review
  7. Islet cell autotransplantation update.CellR4-- repair, replacement, regeneration, & reprogramming · 2019
    Article
  8. Review
  9. A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT).Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2018
    Observational
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Samuel J KesseliSection of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Matthew WagarSection of Endocrinology, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.
Min K JungSection of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Kerrington D SmithSection of General Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Yu Kuei LinDepartment of Endocrinology, Endocrinology and Metabolism Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
R Matthew WalshDepartment of General Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Betul HatipogluSection of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Martin L FreemanSection of Gastroenterology, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.
Timothy L PruettDeparment of Surgery, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.
Gregory J BeilmanDeparment of Surgery, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.
David E R SutherlandDeparment of Surgery, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.
Ty B DunnDeparment of Surgery, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.
David A AxelrodSection of Transplant Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Sushela S ChaidarunSection of Endocrinology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Tyler K StevensSection of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Melena BellinSection of Endocrinology, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.
Timothy B GardnerSection of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
University of Minnesota Medical Center · USCleveland Clinic · USDartmouth–Hitchcock Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTotal pancreatectomy with islet autotransplantation (TPIAT) is increasingly performed with remote islet cell processing and preparation, i.e., with islet cell isolation performed remotely from the primary surgical site at an appropriately equipped islet isolation facility. We aimed to determine whether TPIAT using remote islet isolation results in comparable long-term glycemic outcomes compared with TPIAT performed with standard local isolation.

methodsWe performed a retrospective cohort study of adult patients who underwent TPIAT at three tertiary care centers from 2010 to 2013. Two centers performed remote isolation and one performed local isolation. Explanted pancreata in the remote cohort were transported ∼130 miles to and from islet isolation facilities. The primary outcome was insulin independence 1 year following transplant.

resultsBaseline characteristics were similar between groups except the remote cohort had higher preoperative hemoglobin A1c (HbA1c; 5.43 vs. 5.25, P=0.02) and there were more females in the local cohort (58% vs. 76%, P=0.049). At 1 year, 27% of remote and 32% of local patients were insulin independent (P=0.48). Remote patients experienced a greater drop in fasting c-peptide (-1.66 vs. -0.64, P=0.006) and a greater rise in HbA1c (1.65 vs. 0.99, P=0.014) at 1-year follow-up. A preoperative c-peptide >2.7 (odds ratio (OR) 4.4, 95% confidence interval (CI) 1.6-14.3) and >3,000 islet equivalents/kg (OR 11.0, 95% CI 3.2-37.3) were associated with one-year insulin independence in the local group.

conclusionsAt 1 year after TPIAT, patients undergoing remote surgery have equivalent rates of long-term insulin independence compared with patients undergoing TPIAT locally, but metabolic control is superior with local isolation.

Indexed as

Health FacilitiesAcute DiseaseAdultCohort StudiesC-PeptideDiabetes MellitusFemaleGlycated HemoglobinHumansHypoglycemic AgentsInsulinIslets of Langerhans TransplantationMalePancreatectomyPancreatitisPancreatitis, ChronicC-PeptideGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic AgentsInsulin

Identifiers

PMID28169284
OpenAlexW2586059968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.