ArticleAtherosclerosis2017
Diffuse coronary artery disease among other atherosclerotic plaque characteristics by coronary computed tomography angiography for predicting coronary vessel-specific ischemia by fractional flow reserve.
Article in Atherosclerosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Influence of plaque characteristics by coronary computed tomography angiography on lesion-specific ischemia: a systematic review and meta-analysis.European radiology · 2025Pooled it
- Non-invasive assessment of plaque characteristics in diffuse and focal coronary artery disease; plaque vulnerability and high-risk features.The international journal of cardiovascular imaging · 2026Article
- Plaque burden improves the detection of ischemic CAD over stenosis from coronary computed tomography angiography.The international journal of cardiovascular imaging · 2025Article
- Quantitative Coronary Artery Plaque Parameters and Severity of Ischemia in Patients With INOCA.Circulation. Cardiovascular imaging · 2025Article
- QUIET WARRIOR - Rationale and design: An ancillary study to the Women's IschemiA TRial to Reduce Events in Nonobstructive CAD (WARRIOR).American heart journal plus : cardiology research and practice · 2025Article
- Computed Tomography Evaluation of Coronary Atherosclerosis: The Road Travelled, and What Lies Ahead.Diagnostics (Basel, Switzerland) · 2024Review
- Quantitative flow ratio derived pullback pressure gradient and CZT-SPECT measured longitudinal flow gradient for hemodynamically significant coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Relationship of age, atherosclerosis and angiographic stenosis using artificial intelligence.Open heart · 2021Article
- Risk stratification in coronary artery disease using NHThe international journal of cardiovascular imaging · 2021Article
- The association between the extent of lipidic burden and delta-fractional flow reserve: analysis from coronary physiological and near-infrared spectroscopic measures.Cardiovascular diagnosis and therapy · 2021Article
- Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics.Journal of clinical medicine · 2020Review
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Authors and funding
9 authors.
Funding
Abstract
BACKGROUND AND
aimsCoronary computed tomography angiography (CCTA) permits effective identification of diffuse CAD and atherosclerotic plaque characteristics (APCs). We sought to examine the usefulness of diffuse CAD beyond luminal narrowing and APCs by CCTA to detect vessel-specific ischemia.
methods407 vessels (n = 252 patients) from the DeFACTO diagnostic accuracy study were retrospectively analyzed for percent plaque diffuseness (PD). Percent plaque diffuseness (PD) was obtained on per-vessel level by summation of all contiguous lesion lengths and divided by total vessel length, and was logarithmically transformed (log percent PD). Additional CCTA measures of stenosis severity including minimal lumen diameter (MLD), and APCs, such as positive remodeling (PR) and low attenuation plaque (LAP), were also included. Vessel-specific ischemia was defined as fractional flow reserve (FFR) ≤0.80. Multivariable regression, discrimination by area under the receiver operating characteristic curve (AUC), and category-free net reclassification improvement (cNRI) were assessed.
resultsBackward stepwise logistic regression revealed that for every unit increase in log percent PD, there was a 58% (95% CI: 1.01-2.48, p = 0.048) rise in the odds of having an abnormal FFR, independent of stenosis severity and APCs. The AUC indicated no further improvement in discriminatory ability after adding log percent PD to the final parsimonious model of MLD, PR, and LAP (AUC difference: 0.003, 95% CI: -0.003-0.010, p = 0.33). Conversely, adding log percent PD to the base model of MLD, PR, and LAP improved cNRI by 0.21 (95% CI: 0.01-0.41, p < 0.001).
conclusionsAccounting for diffuse CAD may help improve the accuracy of CCTA for detecting vessel-specific ischemia.
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