Evidence map›Paper›PMID 28168949›Full record

ArticleeLife2017

ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in

Kelly H Oh, James J Haney, Xiaohong Wang, Chiou-Fen Chuang, Janet E Richmond, Hongkyun Kim

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Presynaptic neurons self-tune by inversely coupling neurotransmitter release with the abundance of CaV2 voltage-gated CaProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Article
  6. Active Zone Trafficking of CaV2/UNC-2 Channels Is Independent of β/CCB-1 and α2δ/UNC-36 Subunits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  7. De novo phytosterol synthesis in animals.Science (New York, N.Y.) · 2023
    Article
  8. Regulation of Neurotransmitter Release by KAdvances in neurobiology · 2023
    Article
  9. Article
  10. Article
  11. UNC-2 CaV2 Channel Localization at Presynaptic Active Zones Depends on UNC-10/RIM and SYD-2/Liprin-α inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  12. Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Kelly H OhDepartment of Cell Biology and Anatomy, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States.
James J HaneyDepartment of Cell Biology and Anatomy, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States.
Xiaohong WangDivision of Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, United States.
Chiou-Fen ChuangDivision of Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, United States.
Janet E RichmondDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, United States.
Hongkyun KimDepartment of Cell Biology and Anatomy, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, United States.ORCID 0000-0002-4879-7122
Cincinnati Children's Hospital Medical Center · USRosalind Franklin University of Medicine and Science · USLake Forest College · USUniversity of Illinois Chicago · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Specification of Stochastic Left-Right Asymmetric Neuronal Fates in C. elegansR01GM098026 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHUANG, CHIOU-FEN · 2012 to 2016
$1.5M
Alcohol-induced muscle damage in C. elegansR21AA023940 · NIAAA · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI KIM, HONGKYUN · 2016 to 2017
$410k
NIAAA NIH HHS R21 AA023940NIGMS NIH HHS R01 GM098026NIH HHS P40 OD010440
6 · The paper itself

Abstract

Voltage- and calcium-dependent BK channels regulate calcium-dependent cellular events such as neurotransmitter release by limiting calcium influx. Their plasma membrane abundance is an important factor in determining BK current and thus regulation of calcium-dependent events. In

Indexed as

AlcoholsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCarrier ProteinsEndoplasmic ReticulumLarge-Conductance Calcium-Activated Potassium ChannelsMembrane ProteinsProtein TransportSynapsesAlcoholsCaenorhabditis elegans ProteinsCarrier ProteinsERG-28 protein, C elegansLarge-Conductance Calcium-Activated Potassium ChannelsMembrane Proteinsslo-1 protein, C elegansalcoholBK channelneurosciencesynaptic transmission

Identifiers

PMID28168949
PMCPMC5295816
OpenAlexW2586053034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.