ArticleJournal of integrative plant biology2017
ORA59 and EIN3 interaction couples jasmonate-ethylene synergistic action to antagonistic salicylic acid regulation of PDF expression.
Article in Journal of integrative plant biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 77 citations in OpenAlex.
- Ethylene as the Molecular Coordinator of the Plant Growth-Defense Trade-Off Under Biotic and Abiotic Stresses.International journal of molecular sciences · 2026Review
- A soybean EIN transcription factor confers resistance to Phytophthora sojae and favorable agronomic traits.Plant cell reports · 2026Article
- Genetic mapping and validation of QTL for whitefly resistance in cassava (Manihot esculenta Crantz).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Microbe-Friendly Plants Enable Beneficial Interactions with Soil Rhizosphere Bacteria by Lowering Their Defense Responses.Plants (Basel, Switzerland) · 2024Article
- Arabidopsis WRKY55 Transcription Factor Enhances Soft Rot Disease Resistance with ORA59.The plant pathology journal · 2024Article
- Ethylene: A Modulator of the Phytohormone-Mediated Insect Herbivory Network in Plants.Insects · 2024Review
- Autophagy promotes jasmonate-mediated defense against nematodes.Nature communications · 2023Article
- Tissue-Specific Hormone Signalling and Defence Gene Induction in an In Vitro Assembly of the RapeseedInternational journal of molecular sciences · 2023Article
- Stress Management in Plants: Examining Provisional and Unique Dose-Dependent Responses.International journal of molecular sciences · 2023Review
- Decrypting the multi-functional biological activators and inducers of defense responses against biotic stresses in plants.Heliyon · 2023Review
- Comparative Analysis of Physiological, Hormonal and Transcriptomic Responses Reveal Mechanisms of Saline-Alkali Tolerance in Autotetraploid Rice (International journal of molecular sciences · 2022Article
- Transcriptional regulation of plant innate immunity.Essays in biochemistry · 2022Review
- Exogenous Bio-Based 2,3-Butanediols Enhanced Abiotic Stress Tolerance of Tomato and Turfgrass under Drought or Chilling Stress.Journal of microbiology and biotechnology · 2022Article
- The Effects of Exogenous Salicylic Acid on Endogenous Phytohormone Status inPlants (Basel, Switzerland) · 2022Article
- Dual and opposing roles of EIN3 reveal a generation conflict during seed growth.Molecular plant · 2022Article
- Effect of Qiangdi 863 Nanosynergids Treated Water, Nitrogen, Phosphorous and Potassium Fertilizers on Rice Growth Physiology and Grain Quality.Frontiers in plant science · 2022Article
- The transcription factor ORA59 exhibits dual DNA binding specificity that differentially regulates ethylene- and jasmonic acid-induced genes in plant immunity.Plant physiology · 2021Article
- Involvement of NAC transcription factor NaNAC29 inPlant diversity · 2021Article
- EIN2-directed histone acetylation requires EIN3-mediated positive feedback regulation in response to ethylene.The Plant cell · 2021Article
- Role of Jasmonates, Calcium, and Glutathione in Plants to Combat Abiotic Stresses Through Precise Signaling Cascade.Frontiers in plant science · 2021Review
Corrections and comments
- Erratum issuedErratum.2017
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Hormonal crosstalk is central for tailoring plant responses to the nature of challenges encountered. The role of antagonism between the two major defense hormones, salicylic acid (SA) and jasmonic acid (JA), and modulation of this interplay by ethylene (ET) in favor of JA signaling pathway in plant stress responses is well recognized, but the underlying mechanism is not fully understood. Here, we show the opposing function of two transcription factors, ethylene insensitive3 (EIN3) and EIN3-Like1 (EIL1), in SA-mediated suppression and JA-mediated activation of PLANT DEFENSIN1.2 (PDF1.2). This functional duality is mediated via their effect on protein, not transcript levels of the PDF1.2 transcriptional activator octadecanoid-responsive Arabidopsis59 (ORA59). Specifically, JA induces ORA59 protein levels independently of EIN3/EIL1, whereas SA reduces the protein levels dependently of EIN3/EIL1. Co-infiltration assays revealed nuclear co-localization of ORA59 and EIN3, and split-luciferase together with yeast-two-hybrid assays established their physical interaction. The functional ramification of the physical interaction is EIN3-dependent degradation of ORA59 by the 26S proteasome. These findings allude to SA-responsive reduction of ORA59 levels mediated by EIN3 binding to and targeting of ORA59 for degradation, thus nominating ORA59 pool as a coordination node for the antagonistic function of ET/JA and SA.
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