ReviewOral diseases2017
Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues.
Review in Oral diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- Effect of Vaping on Treatment Outcomes in Patients With Gingivitis, Periodontitis, and/or Peri-Implant Disease: A Systematic Review.Clinical and experimental dental research · 2026Pooled it
- E-cigarettes and nicotine abstinence: a meta-analysis of randomised controlled trials.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- Association between serum cotinine levels and cognitive function in Americans aged 60 and older: A cross-sectional study.Medicine · 2026Article
- Molecular Health Effects of Electronic Cigarettes.Biomolecules · 2026Review
- Vaping Troubles: Exploring the Link Between E-Cigarettes and Oral Lesions in India's Urban Youth.Journal of pharmacy & bioallied sciences · 2025Article
- Selected Population-based Oral Health Assessment Following Usage of E-Cigarettes and Combustible Cigarettes.Oral health & preventive dentistry · 2025Article
- The Impact of Electronic Cigarettes on Oral Health: Analytic Cross-Sectional Study.Journal of pharmacy & bioallied sciences · 2025Article
- E-cigarette: a safe tool or a risk factor for oral cancer? A systematic review.Journal of clinical and experimental dentistry · 2025Review
- Immunological Effects of Electronic Cigarette Use: A Review of Current Evidence.Clinical reviews in allergy & immunology · 2025Review
- Pathophysiological Responses of Oral Keratinocytes After Exposure to Flavored E-Cigarette Liquids.Dentistry journal · 2025Article
- Effect of Nicotine on Pulmonary Pathogenic Bacteria.Current microbiology · 2024Review
- The Effect of New Trend Electronic Cigarettes on Dental Caries in Relation to Glucosyltransferase B and Secretory Immunoglobulin A (A Case-control Study).Cell biochemistry and biophysics · 2024Article
- Oral Mucosa and Saliva Alterations Related to Vape.Clinical and experimental dental research · 2024Article
- Tobacco and menthol flavored nicotine-free electronic cigarettes induced inflammation and dysregulated repair in lung fibroblast and epithelium.Respiratory research · 2024Article
- Electronic Nicotine Delivery Systems Use and Periodontal Health-Findings from the Population Assessment of Tobacco and Health Study.Healthcare (Basel, Switzerland) · 2023Article
- Nicotine affects mitochondrial structure and function in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Functional α7 nicotinic receptors in human airway smooth muscle increase intracellular calcium concentration and contractility in asthmatics.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- A retrospective epidemiological investigation of periodontitis risk and current smoking status based on the number of cigarettes per day and the Fagerström Test for Nicotine Dependence: a preliminary pilot study.Journal of periodontal & implant science · 2023Article
- Perceived Health and Capacity to Cope With Stress in Recent Ex-smokers: Impact of Vaping Versus Quitting All Nicotine.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- The role of the oral microbiome in smoking-related cardiovascular risk: a review of the literature exploring mechanisms and pathways.Journal of translational medicine · 2022Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
E-cigarette-derived inhaled nicotine may contribute to the pathogenesis of periodontal and pulmonary diseases in particular via lung inflammation, injurious, and dysregulated repair responses. Nicotine is shown to have antiproliferative properties and affects fibroblasts in vitro, which may interfere in tissue myofibroblast differentiation in e-cig users. This will affect the ability to heal wounds by decreasing wound contraction. In periodontics, direct exposure to e-vapor has been shown to produce harmful effects in periodontal ligament and gingival fibroblasts in culture. This is due to the generation of reactive oxygen species/aldehydes/carbonyls from e-cig aerosol, leading to protein carbonylation of extracellular matrix and DNA adducts/damage. A limited number of studies regarding the effects of e-cig in oral and lung health are available. However, no reports are available to directly link the deleterious effects on e-cigs, inhaled nicotine, and flavorings aerosol on periodontal and pulmonary health in particular to identify the risk of oral diseases by e-cigarettes and nicotine aerosols. This mini-review summarizes the recent perspectives on e-cigarettes including inhaled nicotine effects on several pathophysiological events, such as oxidative stress, DNA damage, innate host response, inflammation, cellular senescence, profibrogenic and dysregulated repair, leading to lung remodeling, oral submucous fibrosis, and periodontal diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.