Evidence map›Paper›PMID 28168671›Full record

ReviewAdvances in experimental medicine and biology2017

An Integrated Data-Driven Strategy for Safe-by-Design Nanoparticles: The FP7 MODERN Project.

Martin Brehm, Alexander Kafka, Markus Bamler, Ralph Kühne, Gerrit Schüürmann, Lauri Sikk, Jaanus Burk, Peeter Burk, Tarmo Tamm, Kaido Tämm and 12 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Martin BrehmUFZ Department of Ecological Chemistry, Helmholtz Centre for Environmental Research, Permoserstrasse 15, 04318, Leipzig, Germany.
Alexander KafkaUFZ Department of Ecological Chemistry, Helmholtz Centre for Environmental Research, Permoserstrasse 15, 04318, Leipzig, Germany.
Markus BamlerUFZ Department of Ecological Chemistry, Helmholtz Centre for Environmental Research, Permoserstrasse 15, 04318, Leipzig, Germany.
Ralph KühneUFZ Department of Ecological Chemistry, Helmholtz Centre for Environmental Research, Permoserstrasse 15, 04318, Leipzig, Germany.
Gerrit SchüürmannUFZ Department of Ecological Chemistry, Helmholtz Centre for Environmental Research, Permoserstrasse 15, 04318, Leipzig, Germany.
Lauri SikkInstitute of Chemistry, University of Tartu, Ravila 14a, Tartu, 50411, Estonia.
Jaanus BurkInstitute of Chemistry, University of Tartu, Ravila 14a, Tartu, 50411, Estonia.
Peeter BurkInstitute of Chemistry, University of Tartu, Ravila 14a, Tartu, 50411, Estonia.
Tarmo TammInstitute of Technology, University of Tartu, Nooruse 1, Tartu, 50411, Estonia.
Kaido TämmInstitute of Chemistry, University of Tartu, Ravila 14a, Tartu, 50411, Estonia.
Suman PokhrelFoundation Institute of Materials Science (IWT), Department of Production Engineering, University of Bremen, Bremen, Germany.
Lutz MädlerFoundation Institute of Materials Science (IWT), Department of Production Engineering, University of Bremen, Bremen, Germany.
Anne KahruLaboratory of Environmental Toxicology, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn, 12618, Estonia.
Villem AruojaLaboratory of Environmental Toxicology, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn, 12618, Estonia.
Mariliis SihtmäeLaboratory of Environmental Toxicology, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn, 12618, Estonia.
Janeck Scott-FordsmandDepartment of Bioscience, Aarhus Universit, Vejlsovej 25, PO BOX 314, DK, 8600, Silkeborg, Denmark.
Peter B SorensenDepartment of Bioscience, Aarhus Universit, Vejlsovej 25, PO BOX 314, DK, 8600, Silkeborg, Denmark.
Laura EscorihuelaDepartament d'Enginyeria Química, Universitat Rovira i Virgili, Av. Paisos Catalans, 26, 43007, Tarragona, Spain.
Carlos P RocaUFZ Department of Ecological Chemistry, Helmholtz Centre for Environmental Research, Permoserstrasse 15, 04318, Leipzig, Germany.
Alberto FernándezDepartament d'Enginyeria Química, Universitat Rovira i Virgili, Av. Paisos Catalans, 26, 43007, Tarragona, Spain.
Francesc GiraltDepartament d'Enginyeria Química, Universitat Rovira i Virgili, Av. Paisos Catalans, 26, 43007, Tarragona, Spain.
Robert RalloDepartament d'Enginyeria Informatica i Matematiques, Universitat Rovira i Virgili, Av. Paisos Catalans, 26, 43007, Tarragona, Spain. robert.rallo@urv.cat.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development and implementation of safe-by-design strategies is key for the safe development of future generations of nanotechnology enabled products. The safety testing of the huge variety of nanomaterials that can be synthetized is unfeasible due to time and cost constraints. Computational modeling facilitates the implementation of alternative testing strategies in a time and cost effective way. The development of predictive nanotoxicology models requires the use of high quality experimental data on the structure, physicochemical properties and bioactivity of nanomaterials. The FP7 Project MODERN has developed and evaluated the main components of a computational framework for the evaluation of the environmental and health impacts of nanoparticles. This chapter describes each of the elements of the framework including aspects related to data generation, management and integration; development of nanodescriptors; establishment of nanostructure-activity relationships; identification of nanoparticle categories; hazard ranking and risk assessment.

Indexed as

Computer SimulationHumansNanoparticlesNanostructuresNanotechnologyRisk AssessmentSafetyNanodescriptorsNanoinformaticsNanotoxicologyQNARRisk assessment

Identifiers

PMID28168671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.