Evidence map›Paper›PMID 28168623›Full record

ArticleDermatology and therapy2017

A Report of Two Cases of Solid Facial Edema in Acne.

Sarah Kuhn-Régnier, Joanna Mangana, Katrin Kerl, Jivko Kamarachev, Lars E French, Antonio Cozzio, Alexander A Navarini

Abstract read
In one paragraph

Article in Dermatology and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sarah Kuhn-RégnierUniversity of Zurich, Zurich, Switzerland.
Joanna ManganaDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Katrin KerlDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Jivko KamarachevDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Lars E FrenchDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Antonio CozzioDepartment of Dermatology, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland.
Alexander A NavariniDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland. alexander.navarini@usz.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSolid facial edema (SFE) is a rare complication of acne vulgaris. To examine the clinical features of acne patients with solid facial edema, and to give an overview on the outcome of previous topical and systemic treatments in the cases so far published.

methodsWe report two cases from Switzerland, both young men with initially papulopustular acne resistant to topical retinoids.

resultsBoth cases responded to oral isotretinoin, in one case combined with oral steroids. Our cases show a strikingly similar clinical appearance to the cases described by Connelly and Winkelmann in 1985 (Connelly MG, Winkelmann RK. Solid facial edema as a complication of acne vulgaris. Arch Dermatol. 1985;121(1):87), as well as to cases of Morbihan's disease that occurs as a rare complication of rosacea.

conclusionEven 30 years after, the cause of the edema remains unknown. In two of the original four cases, a potential triggering factor was identified such as facial trauma or insect bites; however, our two patients did not report such occurrencies. The rare cases of solid facial edema in both acne and rosacea might hold the key to understanding the specific inflammatory pattern that creates both persisting inflammation and disturbed fluid homeostasis which can occur as a slightly different presentation in dermatomyositis, angioedema, Heerfordt's syndrome and other conditions.

Indexed as

Adrenergic receptorsBrimonidineErythemaRosaceaVasoconstrictionWorsening of erythema

Identifiers

PMID28168623
PMCPMC5336436

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