ArticleThe international journal of cardiovascular imaging2017
Right atrial strain is predictive of clinical outcomes and invasive hemodynamic data in group 1 pulmonary arterial hypertension.
Article in The international journal of cardiovascular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Right Heart Diastology, Where Are We Now?Circulation research · 2026Review
- Regional Ventricular and Global Atrial Strain Characteristics in Patients with Hypoplastic Left Heart Syndrome and Right Ventricular Dysfunction: An Echocardiography, Cardiac MRI, and Invasive Hemodynamics Study.Pediatric cardiology · 2026Article
- Echocardiographic Deformation Imaging of the Right Atrium: A New Paradigm in Noninvasive Hemodynamic Assessment.Current cardiology reports · 2026Review
- Right Atrial Strain in Pediatric Pulmonary Hypertension-A Prospective Observational Study.Pediatric cardiology · 2025Observational
- Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Review
- Prognostic value of right atrial strain in systemic sclerosis based on tissue tracking analysis using cine cardiac magnetic resonance imaging: a retrospective observational study.Heart and vessels · 2024Observational
- Tricuspid Regurgitation Velocity/Tricuspid Annular Plane Systolic Excursion (TRV/TAPSE) Ratio as a Novel Indicator of Disease Severity and Prognosis in Patients with Precapillary Pulmonary Hypertension.Diseases (Basel, Switzerland) · 2023Article
- Echocardiographic evaluation of the right atrial size and function: Relevance for clinical practice.American heart journal plus : cardiology research and practice · 2023Review
- Utility of cardiac magnetic resonance feature tracking strain assessment in chronic thromboembolic pulmonary hypertension for prediction of REVEAL 2.0 high risk status.Pulmonary circulation · 2023Article
- Right atrial function is associated with right venticular diastolic stiffness: RA-RV interaction in pulmonary arterial hypertension.The European respiratory journal · 2022Article
- Echocardiography in Pulmonary Arterial Hypertension: Comprehensive Evaluation and Technical Considerations.Journal of clinical medicine · 2021Review
- Cardiovascular magnetic resonance-assessed fast global longitudinal strain parameters add diagnostic and prognostic insights in right ventricular volume and pressure loading disease conditions.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- Age- and Sex-Specific Changes in CMR Feature Tracking-Based Right Atrial and Ventricular Functional Parameters in Healthy Asians.Frontiers in cardiovascular medicine · 2021Article
- Prediction of Prognostic Hemodynamic Indices in Pulmonary Hypertension Using Non-Invasive Parameters.Diagnostics (Basel, Switzerland) · 2020Article
- Associations of 2D speckle tracking echocardiography-based right heart deformation parameters and invasively assessed hemodynamic measurements in patients with pulmonary hypertension.Cardiovascular ultrasound · 2020Article
- Association of right atrial conduit phase with right ventricular lusitropic function in pulmonary hypertension.The international journal of cardiovascular imaging · 2020Article
- Right atrial function for the prediction of prognosis in connective tissue disease-associated pulmonary arterial hypertension: a study with two-dimensional speckle tracking.The international journal of cardiovascular imaging · 2019Article
- Right Atrial Phasic Function in Heart Failure With Preserved and Reduced Ejection Fraction.JACC. Cardiovascular imaging · 2019Article
- Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension.Circulation. Cardiovascular imaging · 2018Article
- Right Atrial Deformation in Predicting Outcomes in Pediatric Pulmonary Hypertension.Circulation. Cardiovascular imaging · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Transthoracic echocardiography (TTE) is a practical and widely used tool for risk stratification in pulmonary arterial hypertension (PAH). We hypothesized that right atrial (RA) reservoir function, represented by peak RA systolic strain, correlates with invasive hemodynamic measurements and clinical outcomes in PAH. Patients with group 1 PAH who had TTE within 6 months of index PAH clinic visit and right heart catheterization were included in this retrospective study. Peak RA strain in the 2D apical 4-chamber view was measured with speckle-tracking software. The primary endpoint was a composite of prostacyclin initiation, lung transplantation, and death. RA strain was also measured in healthy control subjects. Among the 37 patients studied, 25 (68%) met the primary endpoint. RA strain was significantly lower among patients who met the primary endpoint than among those who did not (mean 20% vs. 33%, P = 0.002). Strain was lower in PAH patients than in controls (mean 24% vs. 35%, P = 0.0001). RA strain correlated negatively with hemodynamic data including RA pressure (R = -0.31), mean pulmonary arterial pressure (R = -0.33), and pulmonary vascular resistance (R = -0.39), and positively with cardiac index (R = 0.44). In receiver operating characteristic analysis to distinguish between patients meeting the primary endpoint and event-free survivors, RA strain was not significantly different from RA volume, right ventricular (RV) fractional area change, RV basal diameter, or right ventricular systolic pressure (area under the curve 0.82, 0.81, 0.83, 0.86, and 0.97, respectively). Our results demonstrate that RA strain is predictive of clinical outcomes in PAH. Further research is needed to determine if RA strain is independently associated with outcomes in this population.
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