ArticleClinical research in cardiology : official journal of the German Cardiac Society2017
Limits of the possible: diagnostic image quality in coronary angiography with third-generation dual-source CT.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 22 citations in OpenAlex.
- Composite cardiac computed tomography angiography score for improved risk assessment in chronic coronary syndromes.Scientific reports · 2025Article
- Machine learning-based coronary heart disease diagnosis model for type 2 diabetes patients.Frontiers in endocrinology · 2025Article
- High Temporal Resolution Dual-Source Photon-Counting CT for Coronary Artery Disease: Initial Multicenter Clinical Experience.Journal of clinical medicine · 2022Article
- Factors influencing the safety of outpatient coronary CT angiography: a clinical registry study.BMJ open · 2022Article
- Quantitative evaluation of coronary artery visibility on CT angiography in Kawasaki disease: young vs. old children.The international journal of cardiovascular imaging · 2021Article
- Coronary CT angiography (CCTA) using third-generation dual-source CT for ruling out in-stent restenosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Echocardiographic calcification score in patients with low/intermediate cardiovascular risk.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Diagnostic performance of machine-learning-based computed fractional flow reserve (FFR) derived from coronary computed tomography angiography for the assessment of myocardial ischemia verified by invasive FFR.The international journal of cardiovascular imaging · 2018Article
- Patient-specific registration of 3D CT angiography (CTA) with X-ray fluoroscopy for image fusion during transcatheter aortic valve implantation (TAVI) increases performance of the procedure.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- The role of noninvasive cardiovascular testing, applied clinical nutrition and nutritional supplements in the prevention and treatment of coronary heart disease.Therapeutic advances in cardiovascular disease · 2018Review
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18 authors at 4 institutions in 1 country.
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Abstract
backgroundThe usage of coronary CT angiography (CTA) is appropriate in patients with acute or chronic chest pain; however the diagnostic accuracy may be challenged with increased Agatston score (AS), increased heart rate, arrhythmia and severe obesity. Thus, we aim to determine the potential of the recently introduced third-generation dual-source CT (DSCT) for CTA in a 'real-life' clinical setting.
methodsTwo hundred and sixty-eight consecutive patients (age: 67 ± 10 years; BMI: 27 ± 5 kg/m²; 61% male) undergoing clinically indicated CTA with DSCT were included in the retrospective single-center analysis. A contrast-enhanced volume dataset was acquired in sequential (SSM) (n = 151) or helical scan mode (HSM) (n = 117). Coronary segments were classified in diagnostic or non-diagnostic image quality. A subset underwent invasive angiography to determine the diagnostic accuracy of CTA.
resultsSSM (96.8 ± 6%) and HSM (97.5 ± 8%) provided no significant differences in the overall diagnostic image quality. However, AS had significant influence on diagnostic image quality exclusively in SSM (B = 0.003; p = 0.0001), but not in HSM. Diagnostic image quality significantly decreased in SSM in patients with AS ≥2,000 (p = 0.03). SSM (sensitivity: 93.9%; specificity: 96.7%; PPV: 88.6%; NPV: 98.3%) and HSM (sensitivity: 97.4%; specificity: 94.3%; PPV: 86.0%; NPV: 99.0%) provided comparable diagnostic accuracy (p = n.s.). SSM yielded significantly lower radiation doses as compared to HSM (2.1 ± 2.0 vs. 5.1 ± 3.3 mSv; p = 0.0001) in age and BMI-matched cohorts.
conclusionSSM in third-generation DSCT enables significant dose savings and provides robust diagnostic image quality in patients with AS ≤2000 independent of heart rate, heart rhythm or obesity.
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