ArticleEuropean radiology2017
Accuracy of iodine quantification using dual energy CT in latest generation dual source and dual layer CT.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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Who cites it
102 citing papers in PubMed, 190 citations in OpenAlex.
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- Quantitative and qualitative evaluation of pancreatic cancer on photon-counting detector CT and dual-energy CT using standard reference images.Abdominal radiology (New York) · 2026Article
- Parameters of dual-layer spectral detector CT for differentiating pathological types of colorectal adenocarcinoma.Insights into imaging · 2026Article
- Quantitative imaging of the central lymphatic system with spectral CT iodine mapping: a feasibility study in swine.medRxiv : the preprint server for health sciences · 2026Article
- Accurate iodine quantification and residual error reduction with principal component analysis multimaterial decomposition using spectral CT.Medical physics · 2026Article
- An in silico evaluation of signal and separability properties of k-edge materials in spectral CT.Scientific reports · 2026Article
- Spectral Computed Tomography for the Detection and Characterization of Communications Between the True and the False Lumen in Aortic Dissections.Investigative radiology · 2026Article
- Assessment of thyroid iodine accumulation following repeated iodinated contrast media administration using dual-energy computed tomography in a rabbit model.Scientific reports · 2026Article
- Assessment of Image Quality Performance of a Photon-Counting Computed Tomography Scanner Approved for Whole-Body Clinical Applications.Sensors (Basel, Switzerland) · 2025Article
- Correlation between perfusion and dual-layer spectral-detector CT in patients with cerebrovascular disorders.European radiology · 2025Article
- Optimizing contrast timing in photon-counting detector CT for the assessment of peripheral arthritis.Skeletal radiology · 2025Article
- Dual-layer spectral CT for iodine mapping and surrogate perfusion evaluation in cerebrovascular disease.European radiology · 2025Article
- Development of a deep learning based approach for multi-material decomposition in spectral CT: a proof of principle in silico study.Scientific reports · 2025Article
- Iodine quantification performance with deep silicon-based Photon-Counting CT: A virtual imaging trial study.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2025Article
- Performance of iodine quantification through high-pitch dual-source photon-counting CT: a phantom study.Japanese journal of radiology · 2025Article
- Impact of patient habitus and acquisition protocol on iodine quantification in dual-source photon-counting computed tomography.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Spectral imaging and analysis of monophasic CT angiography to assess infarct core and penumbra in acute stroke.Scientific reports · 2024Article
- Standardization of Dual-Energy CT Iodine Uptake of the Abdomen and Pelvis: Defining Reference Values in a Big Data Cohort.Diagnostics (Basel, Switzerland) · 2024Article
- Spectral CT in the evaluation of perineural invasion status in rectal cancer.Japanese journal of radiology · 2024Article
- Stationary prospective cardiac gated computed tomography-dynamic study in phantoms andPhysics in medicine and biology · 2024Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the accuracy of iodine quantification with dual energy computed tomography (DECT) in two high-end CT systems with different spectral imaging techniques.
methodsFive tubes with different iodine concentrations (0, 5, 10, 15, 20 mg/ml) were analysed in an anthropomorphic thoracic phantom. Adding two phantom rings simulated increased patient size. For third-generation dual source CT (DSCT), tube voltage combinations of 150Sn and 70, 80, 90, 100 kVp were analysed. For dual layer CT (DLCT), 120 and 140 kVp were used. Scans were repeated three times. Median normalized values and interquartile ranges (IQRs) were calculated for all kVp settings and phantom sizes.
resultsCorrelation between measured and known iodine concentrations was excellent for both systems (R = 0.999-1.000, p < 0.0001). For DSCT, median measurement errors ranged from -0.5% (IQR -2.0, 2.0%) at 150Sn/70 kVp and -2.3% (IQR -4.0, -0.1%) at 150Sn/80 kVp to -4.0% (IQR -6.0, -2.8%) at 150Sn/90 kVp. For DLCT, median measurement errors ranged from -3.3% (IQR -4.9, -1.5%) at 140 kVp to -4.6% (IQR -6.0, -3.6%) at 120 kVp. Larger phantom sizes increased variability of iodine measurements (p < 0.05).
conclusionIodine concentration can be accurately quantified with state-of-the-art DECT systems from two vendors. The lowest absolute errors were found for DSCT using the 150Sn/70 kVp or 150Sn/80 kVp combinations, which was slightly more accurate than 140 kVp in DLCT. KEY POINTS: • High-end CT scanners allow accurate iodine quantification using different DECT techniques. • Lowest measurement error was found in scans with largest photon energy separation. • Dual-source CT quantified iodine slightly more accurately than dual layer CT.
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