ArticleBrain structure & function2017
Effects of aging on T₁, T₂*, and QSM MRI values in the subcortex.
Article in Brain structure & function, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- Volumetric and Intrastructural Characterization of the Substantia Nigra Using Optimized Synthetic MR Images Derived From Quantitative T1 Maps at 3 T.NMR in biomedicine · 2026Article
- The PSP subcortical atlas - a new neuroimaging atlas for progressive supranuclear palsy Richardson's syndrome.NeuroImage. Clinical · 2026Article
- One-Year Substantia NigraMovement disorders : official journal of the Movement Disorder Society · 2026Article
- Disrupted neurovascular-endocrine coupling in type 1 diabetes with impaired awareness of hypoglycemia.The Journal of clinical investigation · 2026Article
- In-vivo histology of Parkinson's disease using quantitative multiparametric mapping.NPJ Parkinson's disease · 2026Article
- Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Using QSM to investigate the iron deposition patterns in deep gray matter nuclei during the aging process in healthy populations.Frontiers in aging neuroscience · 2026Article
- Microstructural changes in locus coeruleus-cortical projections in aged bonnet macaques are independent of myelin loss.Neurobiology of aging · 2026Article
- Latent brain-cognition dimension indicative of neuroinflammatory basis of Long COVID.Brain communications · 2026Article
- Neuroanatomical Changes in the Stopping Network Across the Adult Lifespan Assessed With Quantitative and Diffusion MRI.Human brain mapping · 2025Article
- High-resolution mapping of substantia nigra in Parkinson's disease using 7 tesla magnetic resonance imaging.NPJ Parkinson's disease · 2025Article
- Resting-state functional connectivity in anxiety disorders: a multicenter fMRI study.Molecular psychiatry · 2025Article
- Normative trajectories of RImaging neuroscience (Cambridge, Mass.) · 2025Article
- Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies.Acta neuropathologica · 2024Article
- Assessment of [European journal of nuclear medicine and molecular imaging · 2024Article
- Iron load in the normal aging brain measured with QSM andFrontiers in neuroimaging · 2024Article
- ProbaStem, a pipeline towards the first high-resolution probabilistic atlas of the whole human brainstem.Brain structure & function · 2024Article
- Review
- T1 relaxation time is prolonged in healthy aging: a whole brain study.Turkish journal of medical sciences · 2023Article
- Neuromelanin related ultra-high field signal intensity of the locus coeruleus differs between Parkinson's disease and controls.NeuroImage. Clinical · 2023Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aging brain undergoes several anatomical changes that can be measured with Magnetic Resonance Imaging (MRI). Early studies using lower field strengths have assessed changes in tissue properties mainly qualitatively, using [Formula: see text]- or [Formula: see text]- weighted images to provide image contrast. With the development of higher field strengths (7 T and above) and more advanced MRI contrasts, quantitative measures can be acquired even of small subcortical structures. This study investigates volumetric, spatial, and quantitative MRI parameter changes associated with healthy aging in a range of subcortical nuclei, including the basal ganglia, red nucleus, and the periaqueductal grey. The results show that aging has a heterogenous effects across regions. Across the subcortical areas an increase of [Formula: see text] values is observed, most likely indicating a loss of myelin. Only for a number of areas, a decrease of [Formula: see text] and increase of QSM is found, indicating an increase of iron. Aging also results in a location shift for a number of structures indicating the need for visualization of the anatomy of individual brains.
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