Evidence map›Paper›PMID 28168339›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2017

ISSLS PRIZE IN BIOENGINEERING SCIENCE 2017: Automation of reading of radiological features from magnetic resonance images (MRIs) of the lumbar spine without human intervention is comparable with an expert radiologist.

Amir Jamaludin, Meelis Lootus, Timor Kadir, Andrew Zisserman, Jill Urban, Michele C Battié, Jeremy Fairbank, Iain McCall, Genodisc Consortium

2 registry-linked trialsOpen access · hybridAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 96 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 4 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04239638 withdrawnnot on this mapstarted 2020, after this paper: background citation

Analysis of Cervical Spinal MRI With Deep Learning

TypeobservationalSponsorBezmialem Vakif UniversityRan2020 to 2022Enrolled0ConditionsCervical Disc Disease, Cervical Spine DiseaseArmsCervical Spinal MRI
NCT04527029 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Studies of Early Intelligent Diagnosis of Limb Deformity in Children by AI and Clinic Application

TypeobservationalSponsorChildren's Hospital of Fudan UniversityRan2025 to 2027Enrolled9,000ConditionsLimb DeformityArmsNo interventions
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 4 syntheses or guidelines pooled it, 207 citations in OpenAlex.

  1. Artificial intelligence for segmentation and classification in lumbar spinal stenosis: an overview of current methods.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Pooled it
  2. Are current machine learning applications comparable to radiologist classification of degenerate and herniated discs and Modic change? A systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
    Pooled it
  3. Artificial Intelligence and Computer Aided Diagnosis in Chronic Low Back Pain: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  4. Artificial Intelligence and Computer Vision in Low Back Pain: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  5. Trial
  6. Trial
  7. Identifying scoliosis in a population-based adult cohort: automation of a validated method based on total body dual energy X-ray absorptiometry scans.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  8. Article
  9. External validation of SpineNetv2 deep learning system for automated lumbar spine MRI analysis: A multi-pathology diagnostic agreement study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  10. Advances and challenges in AI-assisted MRI for lumbar disc degeneration detection and classification.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Review
  11. MRI radiomics reveals pain-related biomarkers for modic changes.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  12. Deep learning models for lumbar spinal stenosis on MRI: model comparison and clinical benchmarking.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Comparison of lumbar disc degeneration grading between deep learning model SpineNet and radiologist: a longitudinal study with a 14-year follow-up.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
  18. Article
  19. Review
  20. Artificial intelligence in musculoskeletal applications: a primer for radiologists.Diagnostic and interventional radiology (Ankara, Turkey) · 2025
    Review

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Amir JamaludinDepartment of Engineering Science, University of Oxford, Oxford, UK.
Meelis LootusDepartment of Engineering Science, University of Oxford, Oxford, UK.
Timor KadirMirada Medical, Oxford, UK.
Andrew ZissermanDepartment of Engineering Science, University of Oxford, Oxford, UK.
Jill UrbanDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Michele C BattiéFaculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.
Jeremy FairbankBotnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK. jeremy.fairbank@ndorms.ox.ac.uk.
Iain McCallSpinal Studies, RJAH Orthopaedic Hospital Foundation Trust and ISTM (Keele University), Oswestry, UK.
Genodisc Consortium
University of Oxford · GBMirada Medical (United Kingdom) · GBNuffield Orthopaedic Centre · GBRobert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust · GBUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designInvestigation of the automation of radiological features from magnetic resonance images (MRIs) of the lumbar spine.

objectiveTo automate the process of grading lumbar intervertebral discs and vertebral bodies from MRIs. MR imaging is the most common imaging technique used in investigating low back pain (LBP). Various features of degradation, based on MRIs, are commonly recorded and graded, e.g., Modic change and Pfirrmann grading of intervertebral discs. Consistent scoring and grading is important for developing robust clinical systems and research. Automation facilitates this consistency and reduces the time of radiological analysis considerably and hence the expense.

methods12,018 intervertebral discs, from 2009 patients, were graded by a radiologist and were then used to train: (1) a system to detect and label vertebrae and discs in a given scan, and (2) a convolutional neural network (CNN) model that predicts several radiological gradings. The performance of the model, in terms of class average accuracy, was compared with the intra-observer class average accuracy of the radiologist.

resultsThe detection system achieved 95.6% accuracy in terms of disc detection and labeling. The model is able to produce predictions of multiple pathological gradings that consistently matched those of the radiologist. The model identifies 'Evidence Hotspots' that are the voxels that most contribute to the degradation scores.

conclusionsAutomation of radiological grading is now on par with human performance. The system can be beneficial in aiding clinical diagnoses in terms of objectivity of gradings and the speed of analysis. It can also draw the attention of a radiologist to regions of degradation. This objectivity and speed is an important stepping stone in the investigation of the relationship between MRIs and clinical diagnoses of back pain in large cohorts. LEVEL OF EVIDENCE: Level 3.

Indexed as

Magnetic Resonance ImagingNeural Networks, ComputerRadiologistsBone MarrowHumansIntervertebral DiscIntervertebral Disc DegenerationLumbar VertebraeMaleMiddle AgedSpinal StenosisSpondylolisthesisAutomated gradingDeep learningDisc analysisDisc bulgeDisc classificationDisc detectionDisc herniationModic changesPfirrmann gradingSpondylolisthesisVertebrae analysis

Identifiers

PMID28168339
OpenAlexW2586839650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.