Observational studyJournal of gastroenterology2017
Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease.
Observational study in Journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Association between temperature and global incidence of inflammatory bowel disease.Journal of health, population, and nutrition · 2026Article
- Incidence of Inflammatory Bowel Disease in Children.Gastroenterology research · 2025Article
- Changes in clinical features and seasonal variations of Crohn's disease at diagnosis: a 10-year observational study in China.Frontiers in medicine · 2024Article
- Antidiabetic drugs for IBD: a long but promising road ahead for drug repositioning to target intestinal inflammation.Journal of gastroenterology · 2023Article
- Seasonal variations in gut microbiota and disease course in patients with inflammatory bowel disease.PloS one · 2023Article
- Elderly onset age is associated with low efficacy of first anti-tumor necrosis factor treatment in patients with inflammatory bowel disease.Scientific reports · 2022Observational
- Insolation and Disease Severity in Paediatric Inflammatory Bowel Disease-A Multi-Centre Cross-Sectional Study.Journal of clinical medicine · 2020Article
- Psychologic stress and disease activity in patients with inflammatory bowel disease: A multicenter cross-sectional study.PloS one · 2020Article
- Management of elderly ulcerative colitis in Japan.Journal of gastroenterology · 2019Review
- Development and validation of a web-based questionnaire to identify environmental risk factors for inflammatory bowel disease: the Groningen IBD Environmental Questionnaire (GIEQ).Journal of gastroenterology · 2019Article
- Seasonal Clock Changes Are Underappreciated Health Risks-Also in IBD?Frontiers in medicine · 2019Article
- Evaluation of non-endemic pemphigus foliaceus in a large series of patients: a single-center retrospective study from Turkey focuses on the relapses.Anais brasileiros de dermatologiaArticle
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Authors and funding
21 authors at 14 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnvironmental factors are suggested to affect the pathogenesis of several diseases, including inflammatory bowel disease (IBD). The seasonality of disease onset and exacerbation in IBD, however, are not well established. We herein aimed to clarify the disease seasonality and to investigate the underlying characteristics in IBD patients exhibiting seasonality of the disease course.
methodsThis was a multicenter observational study comprising 20 institutions (Osaka Gut Forum) in Japan. Data were collected from November 2013 to August 2014 using survey forms for physicians and questionnaires for patients. Multivariate analysis was performed to clarify the independent factors affecting disease seasonality.
resultsA total of 1055 patients, including 298 patients with Crohn's disease (CD) and 757 patients with ulcerative colitis (UC), were enrolled. The proportion of CD patients with disease onset in the summer was significantly larger than that in the other seasons, while UC patients exhibited no seasonality of disease onset. More than half of the IBD patients (51.1%) experienced seasonal exacerbation of IBD, and winter was the most common season for disease exacerbation in both CD and UC patients. Seasonality of disease onset and exacerbation was observed in young-onset patients (≤40 years old), but not in elderly-onset patients. Age at onset was independently associated with the seasonality of both disease onset and exacerbation.
conclusionsSeasonality of disease onset and exacerbation was observed especially in young-onset IBD patients. Underlying pathophysiologic triggers for disease initiation and exacerbation may be influenced by age at disease onset.
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