ArticleSchizophrenia bulletin2017
A Neural "Tuning Curve" for Multisensory Experience and Cognitive-Perceptual Schizotypy.
Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 86 citations in OpenAlex.
- The effect of a synthetic cannabinoid agonist (nabilone) on unimodal tactile illusion correlates with a psychometric scores in healthy volunteers.Scientific reports · 2025Trial
- Lower multisensory temporal acuity in individuals with high schizotypal traits: a web-based study.Scientific reports · 2022Trial
- Eye Movement Abnormalities During the Gaze Perception Task in Individuals With Clinical High Risk for Psychosis: A Discriminant Analysis With Hidden Markov Models.Schizophrenia bulletin · 2026Article
- The rhythm of sensory input shapes audio-visual temporal processing.British journal of psychology (London, England : 1953) · 2026Article
- The unique contribution of Schizotypal personality subscales to psychotic-like experiences and social-personality factors in Hong Kong community youths.Frontiers in psychiatry · 2026Article
- Exploring Visuo-Tactile Temporal Binding Window Plasticity in Obsessive-Compulsive Disorder.Biological psychiatry global open science · 2025Article
- Bodily Self-Disturbances and Hallucinations in Schizophrenia.Schizophrenia bulletin · 2025Review
- Respiration Facilitates Behavior During Multisensory Integration.Psychophysiology · 2025Article
- Temporal acuity of vision decreases with eccentricity in virtual reality and is associated with schizotypy.Scientific reports · 2025Article
- Article
- Choice- and trial-history effects on causality perception in Schizophrenia Spectrum Disorder.Schizophrenia (Heidelberg, Germany) · 2025Article
- Predictive role of exteroceptive and interoceptive bodily dimensions to schizotypal personality traits.Scientific reports · 2025Article
- Predictions of bimanual self-touch determine the temporal tuning of somatosensory perception.iScience · 2025Article
- Time in schizophrenia: a link between psychopathology, psychophysics and technology.Translational psychiatry · 2022Review
- A proxy measure of striatal dopamine predicts individual differences in temporal precision.Psychonomic bulletin & review · 2022Article
- Altered Peripersonal Space and the Bodily Self in Schizophrenia: A Virtual Reality Study.Schizophrenia bulletin · 2021Article
- The potential ofPsychopharmacology · 2021Review
- Overcoming Rest-Task Divide-Abnormal Temporospatial Dynamics and Its Cognition in Schizophrenia.Schizophrenia bulletin · 2021Article
- Perceptual Gains and Losses in Synesthesia and Schizophrenia.Schizophrenia bulletin · 2021Article
- The Self and Its Prolonged Intrinsic Neural Timescale in Schizophrenia.Schizophrenia bulletin · 2021Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 5 countries.
Funding
Abstract
Our coherent perception of external events is enabled by the integration of inputs from different senses occurring within a range of temporal offsets known as the temporal binding window (TBW), which varies from person to person. A relatively wide TBW may increase the likelihood that stimuli originating from different environmental events are erroneously integrated and abnormally large TBW has been found in psychiatric disorders characterized by unusual perceptual experiences. Despite strong evidence of inter-individual differences in TBW, both within clinical and nonclinical populations, the neurobiological underpinnings of this variability remain unclear. We adopted an integrated strategy linking TBW to temporal dynamics in functional magnetic resonance imaging (fMRI)-resting-state activity and cortical excitation/inhibition (E/I) balance. E/I balance was indexed by glutamate/Gamma-AminoButyric Acid (GABA) concentrations and common variation in glutamate and GABA genes in a healthy sample. Stronger resting-state long-range temporal correlations, indicated by larger power law exponent (PLE), in the auditory cortex, robustly predicted narrower audio-tactile TBW, which was in turn associated with lower cognitive-perceptual schizotypy. Furthermore, PLE was highest and TBW narrowest for individuals with intermediate levels of E/I balance, with shifts towards either extreme resulting in reduced multisensory temporal precision and increased schizotypy, effectively forming a neural "tuning curve" for multisensory experience and schizophrenia risk. Our findings shed light on the neurobiological underpinnings of multisensory integration and its potentially clinically relevant inter-individual variability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.