ArticleCerebral cortex (New York, N.Y. : 1991)2017
Global and Local Connectivity Differences Converge With Gene Expression in a Neurodevelopmental Disorder of Known Genetic Origin.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Synaptic Function and Sensory Processing in ZDHHC9-Associated Neurodevelopmental Disorder: A Mechanistic Account.The European journal of neuroscience · 2025Article
- Modular community structure of the face network supports face recognition.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Review
- Quantitative mapping of the brain's structural connectivity using diffusion MRI tractography: A review.NeuroImage · 2022Review
- Mapping individual differences across brain network structure to function and behavior with connectome embedding.NeuroImage · 2021Article
- A generative network model of neurodevelopmental diversity in structural brain organization.Nature communications · 2021Observational
- Transdiagnostic Brain Mapping in Developmental Disorders.Current biology : CB · 2020Article
- Functional network dynamics in a neurodevelopmental disorder of known genetic origin.Human brain mapping · 2020Article
- Whole-brain white matter organization, intelligence, and educational attainment.Trends in neuroscience and education · 2019Article
- Children's academic attainment is linked to the global organization of the white matter connectome.Developmental science · 2018Article
- Data-Driven Subtyping of Executive Function-Related Behavioral Problems in Children.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Knowledge of genetic cause in neurodevelopmental disorders can highlight molecular and cellular processes critical for typical development. Furthermore, the relative homogeneity of neurodevelopmental disorders of known genetic origin allows the researcher to establish the subsequent neurobiological processes that mediate cognitive and behavioral outcomes. The current study investigated white matter structural connectivity in a group of individuals with intellectual disability due to mutations in ZDHHC9. In addition to shared cause of cognitive impairment, these individuals have a shared cognitive profile, involving oromotor control difficulties and expressive language impairment. Analysis of structural network properties using graph theory measures showed global reductions in mean clustering coefficient and efficiency in the ZDHHC9 group, with maximal differences in frontal and parietal areas. Regional variation in clustering coefficient across cortical regions in ZDHHC9 mutation cases was significantly associated with known pattern of expression of ZDHHC9 in the normal adult human brain. The results demonstrate that a mutation in a single gene impacts upon white matter organization across the whole-brain, but also shows regionally specific effects, according to variation in gene expression. Furthermore, these regionally specific patterns may link to specific developmental mechanisms, and correspond to specific cognitive deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.