Evidence map›Paper›PMID 28168222›Full record

ArticlemSphere

TgPRELID, a Mitochondrial Protein Linked to Multidrug Resistance in the Parasite

Victoria Jeffers, Edwin T Kamau, Ananth R Srinivasan, Jonathan Harper, Preethi Sankaran, Sarah E Post, Joseph M Varberg, William J Sullivan, Jon P Boyle

Open access · goldAbstract read
In one paragraph

Article in mSphere. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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  6. Non-Vesicular Lipid Transport Machinery inInternational journal of molecular sciences · 2023
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  12. Susceptibility ofEvidence-based complementary and alternative medicine : eCAM · 2019
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  13. Dissection of theeLife · 2018
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  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Victoria JeffersDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-1233-1088
Edwin T KamauDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ananth R SrinivasanDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jonathan HarperDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Preethi SankaranDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sarah E PostDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Joseph M VarbergDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
William J SullivanDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jon P BoyleDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
University of Pittsburgh · USIndiana University School of Medicine

Funding

The GCN5b acetylation complex in the AIDS pathogen ToxoplasmaR01AI116496 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI SULLIVAN, WILLIAM J · 2015 to 2019
$1.9M
Effector diversification and Toxoplasma virulenceR01AI114655 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOYLE, JON P · 2015 to 2019
$1.9M
GCN5-mediated transcription in AIDS pathogen ToxoplasmaR01AI077502 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI SULLIVAN, WILLIAM J · 2009 to 2013
$1.8M
GCN5-mediated transcription in AIDS pathogen ToxoplasmaR56AI077502 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI SULLIVAN, WILLIAM J · 2008 to 2008
$308k
NIAID NIH HHS R01 AI077502NIAID NIH HHS R01 AI114655NIAID NIH HHS R01 AI116496NIAID NIH HHS R56 AI077502
6 · The paper itself

Abstract

New drugs to control infection with the protozoan parasite

Indexed as

mitochondrial protein importmultidrug resistancePRELI domainToxoplasma gondii

Identifiers

PMID28168222
PMCPMC5288566
OpenAlexW2583925942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.