Evidence map›Paper›PMID 28168111›Full record

ArticlePeerJ2017

The prognostic value of tumor length to resectable esophageal squamous cell carcinoma: a retrospective study.

Xiangwei Zhang, Yang Wang, Cheng Li, Jing Helmersson, Yuanzhu Jiang, Guoyuan Ma, Guanghui Wang, Wei Dong, Shaowei Sang, Jiajun Du

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PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiangwei ZhangDepartment of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.
Yang WangDepartment of Medical Imaging, Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.
Cheng LiPresident's Office, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences , Jinan , China.
Jing HelmerssonDepartment of Public Health and Clinical Medicine, Epidemiology and Global Health, Umea University , Umea , Sweden.
Yuanzhu JiangDepartment of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.
Guoyuan MaDepartment of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.
Guanghui WangDepartment of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.
Wei DongDepartment of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.
Shaowei SangClinical Epidemiology Unit, Qilu Hospital of Shandong University , Jinan , China.
Jiajun DuDepartment of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe current TNM classification system does not consider tumor length for patients with esophageal carcinoma (EC). This study explored the effect of tumor length, in addition to tumor depth and lymph node involvement, on survival in patients with esophageal squamous cell carcinoma (ESCC).

methodsA total of 498 ESCC patients who underwent surgical resection as the primary treatment were selected in the retrospective study. Pathological details were collected, which included tumor type, TNM stage, differentiation. Other collected information were: the types of esophageal resection, ABO blood group, family history and demographic and lifestyle factors. A time-dependent receiver operating characteristic (ROC) curve and a regression tree for survival were used to identify the cut-off point of tumor length, which was 3 cm. Univariate and multivariate Cox proportional hazard regression models were used to identify the prognostic factors to ESCC. RESULTS & DISCUSSION: The 1-, 3-, 5-year overall survival rates were found to be 82.5%, 55.6%, and 35.1%, respectively. Patients who had larger tumor length (>3 cm) had a higher risk for death than the rest patients. From the univariate Cox proportional hazards regression model, the overall survival rate was significantly influenced by the depth of the tumor and lymph node involvement (either as dummy or continuous variables), Sex, and tumor length. Using these four variables in the multivariate Cox proportional hazard regression model, we found that the overall survival was significantly influenced by all variables except Sex. Therefore, in addition to the depth of the tumor and lymph node involvement (as either dummy or continuous variables), the tumor length is also an independent prognostic factor for ESCC. The overall survival rate was higher in a group with smaller tumor length (≤3 cm) than those patients with larger tumor length (>3 cm), no matter what the tumor stage was.

conclusionThe tumor length was found to be an important prognostic factor for ESCC patients without receiving neoadjuvant therapy. The modification of EC staging system may consider tumor length to better predict ESCC survival and identify higher risk patients for postoperative therapy.

Indexed as

Esophageal squamous cell carcinomaLong-term survivalPrognostic factor

Identifiers

PMID28168111
PMCPMC5289103

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.