ArticleNeural plasticity2017
Right Hemisphere Remapping of Naming Functions Depends on Lesion Size and Location in Poststroke Aphasia.
Article in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural Resources Supporting Language Production vs. Comprehension in Chronic Post-stroke Aphasia: A Meta-Analysis Using Activation Likelihood Estimates.Frontiers in human neuroscience · 2021Pooled it
- Right Hemisphere Functional Connectivity Increases in Proportion to Left Hemisphere Lesion Size, but Not Within the Language Network.Human brain mapping · 2026Observational
- Right hemisphere language network plasticity in aphasia.Brain : a journal of neurology · 2026Article
- Dynamic network dysregulation in post-stroke aphasia: analysis of dALFF and dynamic functional connectivity.BMC medical imaging · 2026Article
- Article
- Independent contributions of language activations in left and right temporal cortex to aphasia outcomes after stroke.medRxiv : the preprint server for health sciences · 2025Article
- Right Hemisphere Language Network Plasticity in Aphasia.medRxiv : the preprint server for health sciences · 2025Article
- Cerebello-Cerebral Resting-State Functional Connectivity in Poststroke Aphasia.Brain connectivity · 2025Article
- Lesion-Induced Changes to the Network Controllability of the Right Pars Triangularis in Aphasia.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Infratentorial white matter integrity as a potential biomarker for post-stroke aphasia.Brain communications · 2025Article
- Assessing Relative Linguistic Impairment With Model-Based Item Selection.Journal of speech, language, and hearing research : JSLHR · 2024Article
- The role of language-related functional brain regions and white matter tracts in network plasticity of post-stroke aphasia.Journal of neurology · 2024Review
- Article
- The right hemisphere's capacity for language: evidence from primary progressive aphasia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Shared and distinct routes in speech and gesture imitation: Evidence from stroke.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Altered Spontaneous Brain Activity in Poststroke Aphasia: A Resting-State fMRI Study.Brain sciences · 2023Article
- Treatment-induced neural reorganization in aphasia is language-domain specific: Evidence from a large-scale fMRI study.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Preserved anatomical bypasses predict variance in language functions after stroke.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- A Weak Shadow of Early Life Language Processing Persists in the Right Hemisphere of the Mature Brain.Neurobiology of language (Cambridge, Mass.) · 2022Article
- Predictors of Therapy Response in Chronic Aphasia: Building a Foundation for Personalized Aphasia Therapy.Journal of stroke · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of language network plasticity following left hemisphere stroke is foundational to the understanding of aphasia recovery and neural plasticity in general. Damage in different language nodes may influence whether local plasticity is possible and whether right hemisphere recruitment is beneficial. However, the relationships of both lesion size and location to patterns of remapping are poorly understood. In the context of a picture naming fMRI task, we tested whether lesion size and location relate to activity in surviving left hemisphere language nodes, as well as homotopic activity in the right hemisphere during covert name retrieval and overt name production. We found that lesion size was positively associated with greater right hemisphere activity during both phases of naming, a pattern that has frequently been suggested but has not previously been clearly demonstrated. During overt naming, lesions in the inferior frontal gyrus led to deactivation of contralateral frontal areas, while lesions in motor cortex led to increased right motor cortex activity. Furthermore, increased right motor activity related to better naming performance only when left motor cortex was lesioned, suggesting compensatory takeover of speech or language function by the homotopic node. These findings demonstrate that reorganization of language function, and the degree to which reorganization facilitates aphasia recovery, is dependent on the size and site of the lesion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.