ReviewDisease markers2017
Crosstalk between Vitamins A, B12, D, K, C, and E Status and Arterial Stiffness.
Review in Disease markers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05943457 (Efficacy of Vitamin K2 Supplementation in Adult Episodic Migraine), which is not on this map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Vitamin K2 Supplementation in Adult Episodic Migraine
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases-An Umbrella Review.Nutrients · 2020Pooled it
- Heart Involvement in Inflammatory Rheumatic Diseases: A Systematic Literature Review.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Effects of Vitamin D Supplementation on Central Hemodynamic Parameters and Autonomic Nervous System in Obese or Overweight Individuals.Arquivos brasileiros de cardiologia · 2024Trial
- Dietary Vitamin Intake and Central and Peripheral Arterial Stiffness in Patients with Long COVID: The BioICOPER Study.Nutrients · 2026Article
- Association Between Increased Central and Peripheral Arterial 2 Stiffness and Vitamin Intake in Healthy Adults: EVA Follow-Up 3 Study.Nutrients · 2026Article
- Associations between per- and polyfluoroalkyl chemicals and abdominal aortic calcification in middle-aged and older adults.Journal of advanced research · 2025Article
- Vitamin K: Infection, Inflammation, and Auto-Immunity.Journal of inflammation research · 2024Review
- Vascular ageing: moving from bench towards bedside.European journal of preventive cardiology · 2023Article
- The Role of Bile Acids in Cardiovascular Diseases: from Mechanisms to Clinical Implications.Aging and disease · 2023Article
- The Impact of Nutrient Intake and Metabolic Wastes during Pregnancy on Offspring Hypertension: Challenges and Future Opportunities.Metabolites · 2023Review
- Severe COVID-19-A Review of Suggested Mechanisms Based on the Role of Extracellular Matrix Stiffness.International journal of molecular sciences · 2023Review
- Frontiers and hotspots evolution in anti-inflammatory studies for coronary heart disease: A bibliometric analysis of 1990-2022.Frontiers in cardiovascular medicine · 2023Article
- Progress in the application of the neutrophil-to-lymphocyte ratio in dialysis-related complications.Renal failure · 2023Review
- The Roles of Vitamins in Diabetic Retinopathy: A Narrative Review.Journal of clinical medicine · 2022Review
- Blood Reflux-Induced Epigenetic Factors HDACs and DNMTs Are Associated with the Development of Human Chronic Venous Disease.International journal of molecular sciences · 2022Article
- The Effects of Vitamins and Micronutrients onJournal of immunology research · 2022Review
- Role of vitamins in the metabolic syndrome and cardiovascular disease.Pflugers Archiv : European journal of physiology · 2022Review
- Analysis of hot trends in research on the association between vitamin D and cardiovascular disease.Frontiers in nutrition · 2022Article
- Aortic Stiffness and Pulsatile Pressures as Potential Mediators of Chronic Kidney Disease Induced Impaired Diastolic Function.International journal of nephrology and renovascular disease · 2022Article
- The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases.Antioxidants (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arterial stiffness is associated with cardiovascular risk, morbidity, and mortality. The present paper reviews the main vitamins related to arterial stiffness and enabling destiffening, their mechanisms of action, providing a brief description of the latest studies in the area, and their implications for primary cardiovascular prevention, clinical practice, and therapy. Despite inconsistent evidence for destiffening induced by vitamin supplementation in several randomized clinical trials, positive results were obtained in specific populations. The main mechanisms are related to antiatherogenic effects, improvement of endothelial function (vitamins A, C, D, and E) and metabolic profile (vitamins A, B12, C, D, and K), inhibition of the renin-angiotensin-aldosterone system (vitamin D), anti-inflammatory (vitamins A, D, E, and K) and antioxidant effects (vitamins A, C, and E), decrease of homocysteine level (vitamin B12), and reversing calcification of arteries (vitamin K). Vitamins A, B12, C, D, E, and K status is important in evaluating cardiovascular risk, and vitamin supplementation may be an effective, individualized, and inexpensive destiffening therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.