ReviewThe Clinical biochemist. Reviews2016
Acute Kidney Injury: Diagnostic Approaches and Controversies.
Review in The Clinical biochemist. Reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cardiovascular and Renal Outcomes Following Acute Kidney Injury in Pregnancy: A Systematic Review and Meta-Analysis.BJOG : an international journal of obstetrics and gynaecology · 2026Pooled it
- TheFrontiers in physiology · 2026Pooled it
- The efficacy of novel biomarkers for the early detection and management of acute kidney injury: A systematic review.PloS one · 2025Pooled it
- Advancements in early biomarkers of acute kidney injury: from traditional indicators to a paradigm shift in lactate metabolism.Annals of medicine · 2026Review
- Deep-learning time-series anomaly detection of acute kidney injury from creatinine-eGFR trajectories in the ICU.PLOS digital health · 2026Article
- Postoperative acute kidney injury in surgical intensive care units: a multicenter study on incidence and risk profiles.Scientific reports · 2026Article
- An interpretable machine-learning model for early prediction of acute kidney injury in polytrauma patients.Frontiers in medicine · 2026Article
- Pathways to translation for nanomedicine in nephrology.Clinical kidney journal · 2025Review
- Acute Normovolemic Hemodilution Changes the Aquaporin Expression Profile in Specific Tissues and Induces Apoptotic and Inflammatory Processes in a Rat Model.Medicina (Kaunas, Lithuania) · 2025Article
- Modification of the Cardiac Renal Angina Index for Predicting Adverse Kidney Events After Pediatric Cardiac Surgery.Journal of the American Heart Association · 2025Observational
- SepsisCalc: Integrating Clinical Calculators into Early Sepsis Prediction via Dynamic Temporal Graph Construction.KDD : proceedings. International Conference on Knowledge Discovery & Data Mining · 2025Article
- Transfusion Thresholds and Risk Factors of Acute Kidney Injury in Gastrointestinal Oncology Surgery: Insights from a Retrospective Study.Healthcare (Basel, Switzerland) · 2025Article
- Oxalate nephropathy precipitated by linaclotide in a high-risk patient.Clinical nephrology. Case studies · 2025Article
- The Reality of Evaluating Urine Spot Sodium and Urine Spot Sodium Creatinine Ratio in Furosemide Stress Test as a New Biomarker in Diagnosing Progressive AKI in Critically Ill.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Article
- A Systematic Review and Meta-Analysis of MicroRNA as Predictive Biomarkers of Acute Kidney Injury.Biomedicines · 2024Review
- Urine output is an early and strong predictor of acute kidney injury and associated mortality: a systematic literature review of 50 clinical studies.Annals of intensive care · 2024Review
- Article
- Acute Kidney Injury in Neonatal Intensive Care Unit: Epidemiology, Diagnosis and Risk Factors.Journal of clinical medicine · 2024Review
- Hyperbaric Oxygen Reduces Oxidative Stress Impairment and DNA Damage and Simultaneously Increases HIF-1α in Ischemia-Reperfusion Acute Kidney Injury.International journal of molecular sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is a significant independent risk factor for morbidity and mortality. In the last ten years a large number of publications have highlighted the limitations of traditional approaches and the inadequacies of conventional biomarkers to diagnose and monitor renal insufficiency in the acute setting. A great effort was directed not only to the discovery and validation of new biomarkers aimed to detect AKI more accurately but also to standardise the definition of AKI. Despite the advances in both areas, biomarkers have not yet entered into routine clinical practice and the definition of this syndrome has many areas of uncertainty. This review will discuss the controversies in diagnosis and the potential of novel biomarkers to improve the definition of the syndrome.
Identifiers
28167845PMC5242479What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.