ArticleMolecular psychiatry2017
GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder.
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Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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26citing papers in PubMed, 3 pooled it
7.7field-weighted citation impact, top 3% of its field
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.Molecular psychiatry · 2026Pooled it
- Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry.Nature human behaviour · 2026Pooled it
- GLRB variants regulate nearby gene expression in human brain tissues.Scientific reports · 2017Pooled it
- Dynamics of Fear-Generalization Processes and Their Predictive Value for the Development of Anxiety-Related Psychopathology in Adolescents and Adults: A Study Protocol for a Longitudinal Study.International journal of methods in psychiatric research · 2026Article
- Changes in ethanol effects in knock-in mice expressing ethanol insensitive alpha1 and alpha2 glycine receptor subunits.Life sciences · 2024Article
- Glycine Receptor β-Targeting Autoantibodies Contribute to the Pathology of Autoimmune Diseases.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Role of the Glycine Receptor β Subunit in Synaptic Localization and Pathogenicity in Severe Startle Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Startle Disease: New Molecular Insights into an Old Neurological Disorder.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Review
- Article
- Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency.Molecular brain · 2023Article
- Anxiety disorders.Lancet (London, England) · 2021Review
- Genetic and epigenetic analyses of panic disorder in the post-GWAS era.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Anxiety and Startle Phenotypes inFrontiers in molecular neuroscience · 2020Article
- Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning.Neuroscience and biobehavioral reviews · 2019Review
- Genetics of Anxiety Disorders.Current psychiatry reports · 2019Review
- Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes.Translational psychiatry · 2019Article
- A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety.Translational psychiatry · 2018Article
- DNA methylation in adolescents with anxiety disorder: a longitudinal study.Scientific reports · 2018Article
- Inhibition in the amygdala anxiety circuitry.Experimental & molecular medicine · 2018Review
- Impaired Glycine Receptor Trafficking in Neurological Diseases.Frontiers in molecular neuroscience · 2018Review
Corrections and comments
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Authors and funding
47 authors at 20 institutions in 3 countries.
J DeckertDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
H WeberDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
C VillmannDepartment of Clinical Neurobiology, University Hospital of Würzburg, Würzburg, Germany.
T B LonsdorfDepartment of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
J RichterDepartment of Psychology, University of Greifswald, Greifswald, Germany.
M AndreattaDepartment of Psychology, and Center of Mental Health, University of Würzburg, Würzburg, Germany.
A Arias-VasquezDonders Institute for Brain Cognition and Behavior, Departments of Psychiatry, Human Genetics and Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
L HommersDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
L KentSchool of Medicine, University of St Andrews, St Andrews, UK.
C SchartnerDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
S CichonDepartment of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
C WolfDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
N SchaeferDepartment of Clinical Neurobiology, University Hospital of Würzburg, Würzburg, Germany.
C R von CollenbergDepartment of Clinical Neurobiology, University Hospital of Würzburg, Würzburg, Germany.
B WachterDepartment of Clinical Neurobiology, University Hospital of Würzburg, Würzburg, Germany.
R BlumDepartment of Clinical Neurobiology, University Hospital of Würzburg, Würzburg, Germany.
D SchümannDepartment of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
R ScharfenortDepartment of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
J SchumacherDepartment of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
A J ForstnerDepartment of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
C BaumannDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
M A SchieleDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
S NotzonDepartment of Psychiatry and Psychotherapy, University Hospital of Münster, Münster, Germany.
P ZwanzgerDepartment of Psychiatry and Psychotherapy, University Hospital of Münster, Münster, Germany.
J G E JanzingDepartment of Psychiatry Radboud University Medical Center, Nijmegen, The Netherlands.
T GaleslootRadboud Institute for Health Sciences, Radboud University Medical Center, Nijmwegen, The Netherlands.
L A KiemeneyRadboud Institute for Health Sciences, Radboud University Medical Center, Nijmwegen, The Netherlands.
A GajewskaDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
E Glotzbach-SchoonDepartment of Psychology, and Center of Mental Health, University of Würzburg, Würzburg, Germany.
A MühlbergerDepartment of Psychology, University of Regensburg, Regensburg, Germany.
G AlpersDepartment of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
T FydrichDepartment of Psychology, Humboldt University, Berlin, Germany.
L FehmDepartment of Psychology, Humboldt University, Berlin, Germany.
A L GerlachDepartment of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.
T KircherDepartment of Psychiatry and Psychotherapy, University Hospital of Marburg, Marburg, Germany.
T LangDepartment of Clinical Psychology and Psychotherapy, TU Dresden, Dresden, Germany.
A StröhleDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité University Medicine, Berlin, Germany.
V AroltDepartment of Psychiatry and Psychotherapy, University Hospital of Münster, Münster, Germany.
H-U WittchenDepartment of Clinical Psychology and Psychotherapy, TU Dresden, Dresden, Germany.
R KalischNeuroimaging Center (NIC) und Deutsches Resilienz-Zentrum (DRZ), Johannes Gutenberg University Medical Center, Mainz, Germany.
C BüchelDepartment of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
A HammDepartment of Psychology, University of Greifswald, Greifswald, Germany.
M M NöthenDepartment of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
M RomanosDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
K DomschkeDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
P PauliDepartment of Psychology, and Center of Mental Health, University of Würzburg, Würzburg, Germany.
A ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital of Frankfurt, Frankfurt, Germany.
Universitätsklinikum Würzburg · DERadboud University Nijmegen · NLUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Würzburg · DEGoethe University Frankfurt · DEHumboldt-Universität zu Berlin · DELife & Brain (Germany) · DETU Dresden · DEUniversität Greifswald · DEUniversity Hospital Münster · DECharité - Universitätsmedizin Berlin · DEInn-Salzach-Klinikum · DEPhilipps University of Marburg · DERadboud University Medical Center · NLUniversität Hamburg · DEUniversity Hospital Bonn · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DEUniversity of Bonn · DEUniversity of Cologne · DEUniversity of Mannheim · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular genetics of panic disorder (PD) with and without agoraphobia (AG) are still largely unknown and progress is hampered by small sample sizes. We therefore performed a genome-wide association study with a dimensional, PD/AG-related anxiety phenotype based on the Agoraphobia Cognition Questionnaire (ACQ) in a sample of 1370 healthy German volunteers of the CRC TRR58 MEGA study wave 1. A genome-wide significant association was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293, P=3.3 × 10
Indexed as
AdultAgoraphobiaAllelesAnxietyAnxiety DisordersBrainCase-Control StudiesCognitionFearFemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeGermanyHumansGLRB protein, humanReceptors, Glycine
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