Evidence map›Paper›PMID 28167827›Full record

ReviewNature nanotechnology2017

Utilizing the power of Cerenkov light with nanotechnology.

Travis M Shaffer, Edwin C Pratt, Jan Grimm

Abstract readReview
In one paragraph

Review in Nature nanotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Multiplexed imaging of radionuclides.Nature biomedical engineering · 2025
    Review
  6. Radiances of Cerenkov-Emitting Radionuclides on the In Vivo Imaging System.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  7. Article
  8. Review
  9. Laser-Free Photosensitive Systems in Cancer Therapy: A Comprehensive Review.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging.European journal of nuclear medicine and molecular imaging · 2024
    Review
  18. Review
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Travis M ShafferMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Edwin C PrattDepartment of Pharmacology, Weill Cornell Medical College, New York, New York 10021, USA.
Jan GrimmMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Cerenkov luminescence imaging for image-guided cancer surgeryR01CA183953 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI GRIMM, JAN · 2015 to 2019
$2.6M
Cerenkov-emission based nanosensors to detect biologic activities in vivoR01EB014944 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI GRIMM, JAN · 2012 to 2015
$1.6M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA183953NIBIB NIH HHS R01 EB014944
6 · The paper itself

Abstract

The characteristic blue glow of Cerenkov luminescence (CL) arises from the interaction between a charged particle travelling faster than the phase velocity of light and a dielectric medium, such as water or tissue. As CL emanates from a variety of sources, such as cosmic events, particle accelerators, nuclear reactors and clinical radionuclides, it has been used in applications such as particle detection, dosimetry, and medical imaging and therapy. The combination of CL and nanoparticles for biomedicine has improved diagnosis and therapy, especially in oncological research. Although radioactive decay itself cannot be easily modulated, the associated CL can be through the use of nanoparticles, thus offering new applications in biomedical research. Advances in nanoparticles, metamaterials and photonic crystals have also yielded new behaviours of CL. Here, we review the physics behind Cerenkov luminescence and associated applications in biomedicine. We also show that by combining advances in nanotechnology and materials science with CL, new avenues for basic and applied sciences have opened.

Indexed as

Biomedical ResearchLuminescenceNanotechnologyNeoplasmsRadiation, IonizingAnimalsHumansNanoparticlesOptics and Photonics

Identifiers

PMID28167827
PMCPMC5540309

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.