ArticleScientific reports2017
In vivo remineralization of dentin using an agarose hydrogel biomimetic mineralization system.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Application of Polymers in Advanced Materials for Enamel and Dentine Remineralization.ACS biomaterials science & engineering · 2026Review
- From biofilm control to biomimetic remineralization: Hydrogels in prevention and treatment of dental caries.Frontiers in cellular and infection microbiology · 2025Review
- Review
- Harnessing the dental cells derived from human induced pluripotent stem cells for hard tissue engineering.Journal of advanced research · 2024Article
- A Novel Nano-Hydroxyapatite Agarose-Based Hydrogel for Biomimetic Remineralization of Demineralized Human Enamel: An in-vitro Study.Clinical, cosmetic and investigational dentistry · 2024Article
- Remineralization of Dentinal Lesions Using Biomimetic Agents: A Systematic Review and Meta-Analysis.Biomimetics (Basel, Switzerland) · 2023Review
- Research Advances on Hydrogel-Based Materials for Tissue Regeneration and Remineralization in Tooth.Gels (Basel, Switzerland) · 2023Review
- The potential of galactomannan from Caesalpinia ferrea on erosive dentin wear reduction in vitro.Brazilian dental journal · 2023Article
- Integration of hydrogels in microfabrication processes for bioelectronic medicine: Progress and outlook.Frontiers in bioengineering and biotechnology · 2023Review
- Investigation of Different Types of Micro- and Nanostructured Materials for Bone Grafting Application.Nanomaterials (Basel, Switzerland) · 2022Article
- Mussel-inspired polydopamine decorated alginate dialdehyde-gelatin 3D printed scaffolds for bone tissue engineering application.Frontiers in bioengineering and biotechnology · 2022Article
- A Chitosan-Agarose Polysaccharide-Based Hydrogel for Biomimetic Remineralization of Dental Enamel.Biomolecules · 2021Article
- Engineering of a Biomimetic Interface between a Native Dental Tissue and Restorative Composite and Its Study Using Synchrotron FTIR Microscopic Mapping.International journal of molecular sciences · 2021Article
- Biomineralization of Collagen-Based Materials for Hard Tissue Repair.International journal of molecular sciences · 2021Review
- Enhanced silver diamine fluoride therapy using the PILP method -A nanoindentation study.Dental materials journal · 2020Article
- Enhancing Collagen Mineralization with Amelogenin Peptide: Towards the Restoration of Dentin.ACS biomaterials science & engineering · 2020Article
- Regenerating a monoblock to obturate root canalsvia a mineralising strategy.Scientific reports · 2018Article
- Biomimetic remineralization of acid etched enamel using agarose hydrogel model.F1000Research · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel agarose hydrogel biomimetic mineralization system loaded with calcium and phosphate was used to remineralize dentin and induce the oriented densely parallel packed HA layer on defective dentin surface in vivo in a rabbit model. Firstly, the enamel of the labial surface of rabbits' incisor was removed and the dentin was exposed to oral environment. Secondly, the hydrogel biomimetic mineralization system was applied to the exposed dentin surface by using a custom tray. Finally, the teeth were extracted and evaluated by scanning electron microscopy, X-ray diffraction, and nanoindentation test after a certain time of mineralization intervals. The regenerated tissue on the dentin surface was composed of highly organised HA crystals. Densely packed along the c axis, these newly precipitated HA crystals were perpendicular to the underlying dental surface with a tight bond. The demineralized dentin was remineralized and dentinal tubules were occluded by the grown HA crystals. The nanohardness and elastic modulus of the regenerated tissue were similar to natural dentin. The results indicated a potential clinical use for repairing dentin-exposed related diseases, such as erosion, wear, and dentin hypersensitivity.
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Registered trials
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