Evidence map›Paper›PMID 28167789›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Cristina Leoni, Sara Montagner, Andrea Rinaldi, Francesco Bertoni, Sara Polletti, Chiara Balestrieri, Silvia Monticelli

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 137 citations in OpenAlex.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Cristina LeoniInstitute for Research in Biomedicine, Università della Svizzera italiana (USI), 6500 Bellinzona, Switzerland.
Sara MontagnerInstitute for Research in Biomedicine, Università della Svizzera italiana (USI), 6500 Bellinzona, Switzerland.
Andrea RinaldiLymphoma and Genomics Research Program, Institute of Oncology Research (IOR), USI, 6500 Bellinzona, Switzerland.
Francesco BertoniLymphoma and Genomics Research Program, Institute of Oncology Research (IOR), USI, 6500 Bellinzona, Switzerland.
Sara PollettiDepartment of Experimental Oncology, European Institute of Oncology (IEO), 20139 Milan, Italy.
Chiara BalestrieriDepartment of Experimental Oncology, European Institute of Oncology (IEO), 20139 Milan, Italy.
Silvia MonticelliInstitute for Research in Biomedicine, Università della Svizzera italiana (USI), 6500 Bellinzona, Switzerland; silvia.monticelli@irb.usi.ch.
European Institute of Oncology · ITInstitute of Oncology Research · CHUniversità della Svizzera italiana · CHUniversity of Bern · CH

Funding

Swiss National Science Foundation 156875
6 · The paper itself

Abstract

DNA methylation and specifically the DNA methyltransferase enzyme DNMT3A are involved in the pathogenesis of a variety of hematological diseases and in regulating the function of immune cells. Although altered DNA methylation patterns and mutations in

Indexed as

AnimalsAzacitidineCell DegranulationCell ProliferationCells, CulturedDecitabineDermatitis, ContactDisease Models, AnimalDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3ADown-RegulationEnzyme-Linked Immunosorbent AssayEpigenesis, GeneticFemaleAzacitidineDecitabineDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADnmt1 protein, mouseDNMT3A protein, humanDnmt3a protein, mouseImmunoglobulin EInterleukin-3Iqgap2 protein, mouseOxazoloneras GTPase-Activating ProteinsRNA, Small InterferingDNA methylationepigeneticsinflammationmast cells

Identifiers

PMID28167789
PMCPMC5338402
OpenAlexW2587262629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.