Evidence map›Paper›PMID 28167780›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

A distinct subset of plasmacytoid dendritic cells induces activation and differentiation of B and T lymphocytes.

Hong Zhang, Josh D Gregorio, Toru Iwahori, Xiangyue Zhang, Okmi Choi, Lorna L Tolentino, Tyler Prestwood, Yaron Carmi, Edgar G Engleman

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 119 citations in OpenAlex.

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  15. Human CD123Journal of virus eradication · 2025
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hong ZhangDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94304.
Josh D GregorioKyowa Kirin Pharmaceutical Research, La Jolla, CA 92037.
Toru IwahoriSoulage Medical Clinic, Inage-Ku Chiba-City, Chiba, 263-0005, Japan.
Xiangyue ZhangDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94304.
Okmi ChoiStanford Blood Center, Stanford Hospital, Stanford, CA 94304.
Lorna L TolentinoStanford Blood Center, Stanford Hospital, Stanford, CA 94304.
Tyler PrestwoodDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94304.
Yaron CarmiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94304.ORCID 0000-0002-0972-0616
Edgar G EnglemanDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94304; edengleman@stanford.edu.
Stanford University · USStanford Blood Center · USKirin (United States) · US

Funding

TLI/ATG CONDTIONING: KIDNEY/BLOOD STEM CELL TRANSPLANTSP01HL075462 · NHLBI · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G. · 2004 to 2020
$27.9M
Role of Dendritic Cells in Mixed Chimerism and ToleranceR01AI118884 · NIAID · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G., STROBER, SAMUEL · 2015 to 2019
$1.8M
NHLBI NIH HHS P01 HL075462NIAID NIH HHS R01 AI118884
6 · The paper itself

Abstract

Plasmacytoid dendritic cells (pDCs) are known mainly for their secretion of type I IFN upon viral encounter. We describe a CD2

Indexed as

Cell DifferentiationLymphocyte ActivationAnimalsB-LymphocytesCD2 AntigensCD5 AntigensCell ProliferationCell SeparationDendritic CellsFlow CytometryHumansInterferon Type IMaleMiceMice, Inbred C57BLOligodeoxyribonucleotidesCD2 AntigensCD5 AntigensCPG-oligonucleotideInterferon Type IOligodeoxyribonucleotidesTetraspanin 28Toll-Like ReceptorsCD2CD5CD81plasmacytoid dendritic cellstype I IFN

Identifiers

PMID28167780
PMCPMC5338447
OpenAlexW2587291131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.