Evidence map›Paper›PMID 28167697›Full record

ArticleThe EMBO journal2017

PRC2 is dispensable for

Manuela Portoso, Roberta Ragazzini, Živa Brenčič, Arianna Moiani, Audrey Michaud, Ivaylo Vassilev, Michel Wassef, Nicolas Servant, Bruno Sargueil, Raphaël Margueron

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 175 citations in OpenAlex.

  1. Article
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  3. Epigenetic regulation of EZH2 by ncRNAs: mechanisms and oncogenic implications.Naunyn-Schmiedeberg's archives of pharmacology · 2026
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  17. ST8SIA6-AS1, a novel lncRNA star in liver cancer.Frontiers in cell and developmental biology · 2024
    Review
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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Manuela PortosoInstitut Curie, PSL Research University, Paris, France.
Roberta RagazziniInstitut Curie, PSL Research University, Paris, France.
Živa BrenčičInstitut Curie, PSL Research University, Paris, France.
Arianna MoianiInstitut Curie, PSL Research University, Paris, France.
Audrey MichaudInstitut Curie, PSL Research University, Paris, France.
Ivaylo VassilevInstitut Curie, PSL Research University, Paris, France.
Michel WassefInstitut Curie, PSL Research University, Paris, France.
Nicolas ServantInstitut Curie, PSL Research University, Paris, France.
Bruno SargueilCNRS UMR 8015, Université Paris Descartes, Paris, France.
Raphaël MargueronInstitut Curie, PSL Research University, Paris, France raphael.margueron@curie.fr.ORCID 0000-0002-9093-7977
Centre National de la Recherche Scientifique · FRDélégation Paris 5 · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) play diverse roles in physiological and pathological processes. Several lncRNAs have been suggested to modulate gene expression by guiding chromatin-modifying complexes to specific sites in the genome. However, besides the example of Xist, clear-cut evidence demonstrating this novel mode of regulation remains sparse. Here, we focus on

Indexed as

Gene Expression Regulation, NeoplasticGene SilencingTranscription, GeneticBreast NeoplasmsCell Line, TumorFemaleHumansNeoplasm ProteinsPolycomb Repressive Complex 2RNA, Long NoncodingRNA, NeoplasmHOTAIR long untranslated RNA, humanNeoplasm ProteinsPolycomb Repressive Complex 2RNA, Long NoncodingRNA, NeoplasmchromatinlincRNAPolycombtranscription

Identifiers

PMID28167697
PMCPMC5391141
OpenAlexW2586972673

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.