Evidence map›Paper›PMID 28167672›Full record

ArticleInfection and immunity2017

Anthelmintic Therapy Modifies the Systemic and Mycobacterial Antigen-Stimulated Cytokine Profile in Helminth-Latent Mycobacterium tuberculosis Coinfection.

Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Chandrakumar Dolla, Paul Kumaran, Thomas B Nutman, Subash Babu

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Impact ofOpen forum infectious diseases · 2025
    Article
  4. Article
  5. Intestinal Parasitic Infections May Be Overlooked Drivers of the Tuberculosis Pandemic.The American journal of tropical medicine and hygiene · 2024
    Article
  6. Article
  7. Review
  8. Cytokine Responses duringMicroorganisms · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. CD4 T Cells inFrontiers in immunology · 2020
    Article
  16. QuantiFERONThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2019
    Article
  17. Article
  18. When do co-infections matter?Current opinion in infectious diseases · 2018
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Rajamanickam AnuradhaNational Institutes of Health-NIRT-International Center for Excellence in Research, Chennai, India.
Saravanan MunisankarNational Institutes of Health-NIRT-International Center for Excellence in Research, Chennai, India.
Yukthi BhootraNational Institutes of Health-NIRT-International Center for Excellence in Research, Chennai, India.
Chandrakumar DollaNational Institute for Research in Tuberculosis, Chennai, India.
Paul KumaranNational Institute for Research in Tuberculosis, Chennai, India.
Thomas B NutmanLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Subash BabuNational Institutes of Health-NIRT-International Center for Excellence in Research, Chennai, India sbabu@mail.nih.gov.
International Centers for Excellence in Research · INNational Institute of Research in Tuberculosis · INNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · US

Funding

Immunoregulation /Immune Recognition In Filarial/Nonfilarial Parasitic InfectionZIAAI000197 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$23.4M
India International Center for Excellence in ResearchZIAAI001065 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$19.0M
6 · The paper itself

Abstract

Helminth infections are known to modulate cytokine responses in latent tuberculosis (LTB). However, very few studies have examined whether this modulation is reversible upon anthelmintic therapy. We measured the systemic and mycobacterial (TB) antigen-stimulated levels of type 1, type 2, type 17, and regulatory cytokines in individuals with LTB and with or without coexistent

Indexed as

CoinfectionMycobacterium tuberculosisAdultAnimalsAnthelminticsAntigens, BacterialCytokinesFemaleHelminthiasisHelminthsHost-Parasite InteractionsHost-Pathogen InteractionsHumansLatent TuberculosisMaleMiddle AgedAnthelminticsAntigens, BacterialCytokinescytokineshelminthsimmune responsesStrongyloidestuberculosis

Identifiers

PMID28167672
PMCPMC5364310
OpenAlexW2586400978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.