ArticleInfection and immunity2017
Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival.
Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- NFIA regulates articular chondrocyte fatty acid metabolism and joint homeostasis.Science translational medicine · 2025Article
- Loss of NFIA Impairs Adult Hippocampal Neurogenesis.Hippocampus · 2025Article
- Article
- The miR-223/nuclear factor I-A axis regulates inflammation and cellular functions in intestinal tissues with necrotizing enterocolitis.FEBS open bio · 2021Article
- Imidazo[1,2-International journal of molecular sciences · 2020Article
- HuR promotes miRNA-mediated upregulation of NFI-A protein expression in MDSCs during murine sepsis.Molecular immunology · 2020Article
- Long Non-Coding RNA Hotairm1 Promotes S100A9 Support of MDSC Expansion during Sepsis.Journal of clinical & cellular immunology · 2020Article
- S100A9 maintains myeloid-derived suppressor cells in chronic sepsis by inducing miR-21 and miR-181b.Molecular immunology · 2019Article
- Neutrophil Diversity in Health and Disease.Trends in immunology · 2019Review
- Myeloid-Derived Suppressor Cells in Sepsis.Frontiers in immunology · 2019Review
- Advances in the understanding and treatment of sepsis-induced immunosuppression.Nature reviews. Nephrology · 2018Review
- The Yin and Yang of Myeloid Derived Suppressor Cells.Frontiers in immunology · 2018Review
- Nfia deletion in myeloid cells blocks expansion of myeloid-derived suppressor cells during sepsis.Innate immunity · 2018Article
- MDSCs are induced after experimental blunt chest trauma and subsequently alter antigen-specific T cell responses.Scientific reports · 2017Article
- Monocytic Myeloid-Derived Suppressor Cells in Chronic Infections.Frontiers in immunology · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Myeloid progenitor-derived suppressor cells (MDSCs) arise from myeloid progenitors and suppress both innate and adaptive immunity. MDSCs expand during the later phases of sepsis in mice, promote immunosuppression, and reduce survival. Here, we report that the myeloid differentiation-related transcription factor nuclear factor I-A (NFI-A) controls MDSC expansion during sepsis and impacts survival. Unlike MDSCs, myeloid cells with conditional deletion of the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.