Evidence map›Paper›PMID 28167639›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2017

Therapeutic Restoration of Endothelial Glycocalyx in Sepsis.

J W Song, J A Zullo, D Liveris, M Dragovich, X F Zhang, M S Goligorsky

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Manuscript DMD-D-25-00346 The impact of glycocalyx on partitioning and distribution of basic drugs.Drug metabolism and disposition: the biological fate of chemicals · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Endothelial Glycocalyx Damage and Restoration Following Vascular Stent Implantation.Journal of cardiovascular translational research · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Observational
  19. Article
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

J W SongRenal Research Institute and Departments of Medicine, Pharmacology and Physiology (J.A.Z., M.S.G.), and Department of Microbiology (D.L.), New York Medical College, Valhalla, New York; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea (J.W.S.); and Department of Mechanical Engineering and Mechanics, and Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania (M.D., X.F.Z.) sjw72331@yuhs.ac.
J A ZulloRenal Research Institute and Departments of Medicine, Pharmacology and Physiology (J.A.Z., M.S.G.), and Department of Microbiology (D.L.), New York Medical College, Valhalla, New York; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea (J.W.S.); and Department of Mechanical Engineering and Mechanics, and Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania (M.D., X.F.Z.).
D LiverisRenal Research Institute and Departments of Medicine, Pharmacology and Physiology (J.A.Z., M.S.G.), and Department of Microbiology (D.L.), New York Medical College, Valhalla, New York; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea (J.W.S.); and Department of Mechanical Engineering and Mechanics, and Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania (M.D., X.F.Z.).
M DragovichRenal Research Institute and Departments of Medicine, Pharmacology and Physiology (J.A.Z., M.S.G.), and Department of Microbiology (D.L.), New York Medical College, Valhalla, New York; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea (J.W.S.); and Department of Mechanical Engineering and Mechanics, and Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania (M.D., X.F.Z.).
X F ZhangRenal Research Institute and Departments of Medicine, Pharmacology and Physiology (J.A.Z., M.S.G.), and Department of Microbiology (D.L.), New York Medical College, Valhalla, New York; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea (J.W.S.); and Department of Mechanical Engineering and Mechanics, and Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania (M.D., X.F.Z.).
M S GoligorskyRenal Research Institute and Departments of Medicine, Pharmacology and Physiology (J.A.Z., M.S.G.), and Department of Microbiology (D.L.), New York Medical College, Valhalla, New York; Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, South Korea (J.W.S.); and Department of Mechanical Engineering and Mechanics, and Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania (M.D., X.F.Z.) sjw72331@yuhs.ac.
New York Medical College · USLehigh University · USYonsei University · KR

Funding

RENAL ENDOTHELIAL AND SMOOTH MUSCLE CELLS INTERACTIONSR01DK045462 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI GOLIGORSKY, MICHAEL S · 1995 to 2014
$4.8M
VASCULAR PERMEABILITY IN DIABETIC NEPHROPATHYR01DK054602 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI GOLIGORSKY, MICHAEL S · 1999 to 2010
$2.5M
Endothelial dysfunction in acute renal ischemiaR01DK052783 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI GOLIGORSKY, MICHAEL S · 1997 to 2007
$2.0M
NIDDK NIH HHS R01 DK045462NIDDK NIH HHS R01 DK052783NIDDK NIH HHS R01 DK054602
6 · The paper itself

Abstract

Endothelial glycocalyx (EG) is disintegrated during sepsis. We have previously shown that this occurs very early in the course of sepsis and its prevention improves the survival of mice with sepsis. Here, we sought to investigate the possibility of pharmacologically accelerating the restoration of disintegrated EG in sepsis. We used a soilage injection model to induce polymicrobial sepsis in C57/BL6 mice and measured total body EG. En face aortic preparations were used for staining of markers of EG and atomic force microscopy was used to measure EG in vitro. In vitro studies were conducted in cultured endothelial cells either exposed to a lipopolysaccharide or enzymatically denuded of EG. Sulodexide (SDX), a heparin sulfate-like compound resistant to degradation by heparanase, accelerated EG regeneration in vitro and in vivo. The total volume of EG was drastically reduced in septic mice. Administration of SDX produced a dramatic acceleration of EG restoration. This effect, unrelated to any SDX-induced differences in microbial burden, was associated with better control of vascular permeability. Notably, SDX demonstrated not only a remarkable capacity for EG regeneration in vitro and in vivo but was also associated with improved animal survival, even when instituted 2 hours after induction of severe sepsis. In conclusion, 1) EG is disintegrated in sepsis, the event which contributes to high animal mortality; 2) pharmacologic acceleration of EG restoration can be achieved using SDX; and 3) SDX reduces vascular permeability, which is elevated in septic mice, and improves animal survival.

Indexed as

AnimalsAnticoagulantsCapillary PermeabilityCells, CulturedEndothelial CellsGlycocalyxGlycosaminoglycansMaleMiceMice, Inbred C57BLSepsisAnticoagulantsglucuronyl glucosamine glycan sulfateGlycosaminoglycans

Identifiers

PMID28167639
PMCPMC5363766
OpenAlexW2586856403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.