Evidence map›Paper›PMID 28167638›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2017

Effects of Repeated Ropinirole Treatment on Phencyclidine-Induced Hyperlocomotion, Prepulse Inhibition Deficits, and Social Avoidance in Rats.

Amanda M Maple, Tanessa Call, Phylicia C Kimmel, Ronald P Hammer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. In Vitro and In Vivo Sequestration of Phencyclidine by MeChemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amanda M MapleDepartment of Basic Medical Sciences (A.M.M., P.C.K., R.P.H.), and Departments of Pharmacology and Psychiatry (R.P.H.), University of Arizona College of Medicine, Phoenix; and Department of Psychology (A.M.M., P.C.K., R.P.H.) and Interdisciplinary Graduate Program in Neuroscience (T.C., R.P.H.), Arizona State University, Tempe, Arizona.
Tanessa CallDepartment of Basic Medical Sciences (A.M.M., P.C.K., R.P.H.), and Departments of Pharmacology and Psychiatry (R.P.H.), University of Arizona College of Medicine, Phoenix; and Department of Psychology (A.M.M., P.C.K., R.P.H.) and Interdisciplinary Graduate Program in Neuroscience (T.C., R.P.H.), Arizona State University, Tempe, Arizona.
Phylicia C KimmelDepartment of Basic Medical Sciences (A.M.M., P.C.K., R.P.H.), and Departments of Pharmacology and Psychiatry (R.P.H.), University of Arizona College of Medicine, Phoenix; and Department of Psychology (A.M.M., P.C.K., R.P.H.) and Interdisciplinary Graduate Program in Neuroscience (T.C., R.P.H.), Arizona State University, Tempe, Arizona.
Ronald P HammerDepartment of Basic Medical Sciences (A.M.M., P.C.K., R.P.H.), and Departments of Pharmacology and Psychiatry (R.P.H.), University of Arizona College of Medicine, Phoenix; and Department of Psychology (A.M.M., P.C.K., R.P.H.) and Interdisciplinary Graduate Program in Neuroscience (T.C., R.P.H.), Arizona State University, Tempe, Arizona ron.hammer@arizona.edu.
Arizona State University · US

Funding

Neural Plasticity and Sensorimotor Gating in RatsR01MH073930 · NIMH · UNIVERSITY OF ARIZONA · PI HAMMER, RONALD P. · 2006 to 2010
$1.3M
NIMH NIH HHS R01 MH073930
6 · The paper itself

Abstract

Phencyclidine (PCP), a noncompetitive N-methyl d-aspartate (NMDA) receptor antagonist, provides the most complete pharmacologic model of schizophrenia in humans and animals. Acute PCP causes hyperlocomotion, disrupts prepulse inhibition (PPI), and increases social avoidance in rats. We have previously shown that repeated treatment with the dopamine (DA) D

Indexed as

AnimalsAvoidance LearningDopamine AgonistsHyperkinesisIndolesMalePhencyclidinePrepulse InhibitionRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSchizophreniaSocial BehaviorTreatment OutcomeDopamine AgonistsIndolesPhencyclidineReceptors, N-Methyl-D-Aspartateropinirole

Identifiers

PMID28167638
PMCPMC11047206
OpenAlexW2586355819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.