Evidence map›Paper›PMID 28167604›Full record

ArticleMolecular and cellular biology2017

Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling.

Dmitry Akhmedov, Maria G Mendoza-Rodriguez, Kavitha Rajendran, Mario Rossi, Jürgen Wess, Rebecca Berdeaux

Open access · hybridAbstract read
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. GNature communications · 2024
    Article
  8. Article
  9. Article
  10. Identification of GαScientific reports · 2024
    Article
  11. The GPCR-GαNature immunology · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Stimulation of the Epithelial NaFrontiers in physiology · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dmitry AkhmedovDepartment of Integrative Biology and Pharmacology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Maria G Mendoza-RodriguezDepartment of Integrative Biology and Pharmacology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Kavitha RajendranDepartment of Integrative Biology and Pharmacology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Mario RossiMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Jürgen WessMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Rebecca BerdeauxDepartment of Integrative Biology and Pharmacology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas, USA Rebecca.Berdeaux@uth.tmc.edu.ORCID http://orcid.org/0000-0002-9929-1711
The University of Texas Health Science Center at Houston · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Regulation of glucose utilization by skeletal muscle SIK1R01DK092590 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BERDEAUX, REBECCA L · 2011 to 2021
$3.3M
The role of SIK1 in myogenic differentiation and skeletal muscle repairR01AR059847 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BERDEAUX, REBECCA L · 2011 to 2015
$1.7M
NIAMS NIH HHS R01 AR059847NIDDK NIH HHS R01 DK092590
6 · The paper itself

Abstract

Hundreds of hormones and ligands stimulate cyclic AMP (cAMP) signaling in different tissues through the activation of G-protein-coupled receptors (GPCRs). Although the functions and individual effectors of cAMP signaling are well characterized in many tissues, pleiotropic effects of GPCR agonists limit investigations of physiological functions of cAMP signaling in individual cell types at different developmental stages

Indexed as

AnimalsBlood GlucoseCells, CulturedClozapineCyclic AMPCyclic AMP Response Element-Binding ProteinGlucoseGreen Fluorescent ProteinsHepatocytesHyperglycemiaIntegrasesLiverMiceMice, Inbred C57BLMice, TransgenicReceptors, G-Protein-CoupledBlood GlucoseClozapineclozapine N-oxideCreb1 protein, mouseCre recombinaseCyclic AMPCyclic AMP Response Element-Binding ProteinGlucoseGreen Fluorescent ProteinsGt(ROSA)26Sor non-coding RNA, mouseIntegrasesReceptors, G-Protein-CoupledRNA, Untranslatedbioluminescence imagingCREBcyclic AMPDREADDglucose metabolismGPCRliver

Identifiers

PMID28167604
PMCPMC5394278
OpenAlexW2587273239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.