Evidence map›Paper›PMID 28167561›Full record

ArticleAntimicrobial agents and chemotherapy2017

Functional Characterization of the DNA Gyrases in Fluoroquinolone-Resistant Mutants of Francisella novicida.

Yvan Caspar, Claire Siebert, Vivien Sutera, Corinne Villers, Alexandra Aubry, Claudine Mayer, Max Maurin, Patricia Renesto

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Intracellular Experimental Evolution ofACS infectious diseases · 2023
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  4. Characterization of threeAccess microbiology · 2023
    Article
  5. Review
  6. Article
  7. Genetic Determinants of Antibiotic Resistance inFrontiers in microbiology · 2021
    Review
  8. Article
  9. Emerging microbes & infections · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Yvan CasparTIMC-IMAG UMR 5525, UGA CNRS, Grenoble, France.
Claire SiebertTIMC-IMAG UMR 5525, UGA CNRS, Grenoble, France.
Vivien SuteraCentre Hospitalier Universitaire Grenoble-Alpes, Centre National de Référence des Francisella, CS 10217, Grenoble, France.
Corinne VillersTIMC-IMAG UMR 5525, UGA CNRS, Grenoble, France.
Alexandra AubrySorbonne Université, UPMC Université Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses, Team 13, INSERM U1135, Paris, France.
Claudine MayerInstitut Pasteur, Paris, France.
Max MaurinTIMC-IMAG UMR 5525, UGA CNRS, Grenoble, France.
Patricia RenestoTIMC-IMAG UMR 5525, UGA CNRS, Grenoble, France patricia.renesto@univ-grenoble-alpes.fr.
Université Grenoble Alpes · FRCentre Hospitalier Universitaire de Grenoble · FRCentre National de la Recherche Scientifique · FRCNR de la Résistance aux Antibiotiques · FRDélégation Paris 7 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluoroquinolone (FQ) resistance is a major health concern in the treatment of tularemia. Because DNA gyrase has been described as the main target of these compounds, our aim was to clarify the contributions of both GyrA and GyrB mutations found in

Indexed as

Genome, BacterialMutationAmino Acid MotifsAmino Acid SubstitutionAnti-Bacterial AgentsBinding SitesCloning, MolecularDNA GyraseDNA Topoisomerase IVDrug Resistance, BacterialEscherichia coliFluoroquinolonesFrancisellaGene ExpressionHigh-Throughput Nucleotide SequencingMicrobial Sensitivity TestsAnti-Bacterial AgentsDNA GyraseDNA Topoisomerase IVFluoroquinolonesRecombinant ProteinsDNA gyrasefluoroquinolonesFrancisella

Identifiers

PMID28167561
PMCPMC5365679
OpenAlexW2586095907

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.