Evidence map›Paper›PMID 28167233›Full record

ReviewCellular signalling2018

Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system.

Steven S An, Stephen B Liggett

Open access · hybridAbstract readReview
In one paragraph

Review in Cellular signalling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 88 citations in OpenAlex.

  1. Asthma endotypes and theratypes.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  2. Alginate-Based Beads ContainingGels (Basel, Switzerland) · 2026
    Article
  3. Transcriptomic Changes in Mouse Lung Tissue after a Long-Term Space Flight.Bulletin of experimental biology and medicine · 2025
    Article
  4. Article
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  10. Article
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  12. GPCRs and fibroblast heterogeneity in fibroblast-associated diseases.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Review
  13. TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Olfactory receptors contribute to progression of kidney fibrosis.NPJ systems biology and applications · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Steven S AnDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, United States. Electronic address: san@jhu.edu.
Stephen B LiggettDepartment of Internal Medicine, Center for Personalized Medicine and Genomics, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd., MDC 2, Tampa, FL 33612, United States; Department of Pharmacology and Physiology, Center for Personalized Medicine and Genomics, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd., MDC 2, Tampa, FL 33612, United States. Electronic address: sliggett@health.usf.edu.
Johns Hopkins University · USUniversity of South Florida · US

Funding

Project 4 - OGR1- and TSPO- dependent mechanisms mediated by benzodiazepines affecting ASM contractionP01HL114471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LIGGETT, STEPHEN B · 2013 to 2023
$23.9M
Molecular properties of B-adrenergic receptors in AsthmaR37HL045967 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LIGGETT, STEPHEN B · 2002 to 2012
$3.2M
Nrf2 as a critical determinant of smooth muscle functionR01HL107361 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI AN, STEVEN S · 2011 to 2015
$2.0M
MOLECULAR PROPERTIES OF B-ADRENERGIC RECEPTORS IN ASTHMAR01HL045967 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LIGGETT, STEPHEN B · 1990 to 2018
$1.3M
Molecular properties of B-adrenergic receptors in AsthmaR56HL045967 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LIGGETT, STEPHEN B · 2015 to 2015
$374k
NHLBI NIH HHS P01 HL114471NHLBI NIH HHS R01 HL045967NHLBI NIH HHS R01 HL107361NHLBI NIH HHS R37 HL045967NHLBI NIH HHS R56 HL045967
6 · The paper itself

Abstract

Taste and smell receptor expression has been traditionally limited to the tongue and nose. We have identified bitter taste receptors (TAS2Rs) and olfactory receptors (ORs) on human airway smooth muscle (HASM) cells. TAS2Rs signal to PLCβ evoking an increase in [Ca

Indexed as

AnimalsAsthmaGastrointestinal MicrobiomeHumansLungMiceMice, KnockoutModels, AnimalMyocytes, Smooth MuscleReceptors, G-Protein-CoupledReceptors, OdorantSmellTasteReceptors, G-Protein-CoupledReceptors, OdorantAirwayAsthmaBronchodilatorG-proteinReceptorSmooth muscle

Identifiers

PMID28167233
PMCPMC5939926
OpenAlexW2585049727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.