Evidence map›Paper›PMID 28167132›Full record

ArticleHearing research2017

Identification of induced and naturally occurring conductive hearing loss in mice using bone conduction.

David Chhan, Melissa L McKinnon, John J Rosowski

Abstract read
In one paragraph

Article in Hearing research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Cochlin Deficiency Protects Against Noise-Induced Hearing Loss.Frontiers in molecular neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

David ChhanArmy Research Lab, Aberdeen Proving Ground, MD, USA. Electronic address: d.chann1@gmail.com.
Melissa L McKinnonEaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. Electronic address: Melissa_McKinnon@meei.harvard.edu.
John J RosowskiEaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; Department of Otolaryngology, Harvard Medical School, Boston, MA, USA. Electronic address: john_rosowski@meei.harvard.edu.
Massachusetts Eye and Ear Infirmary · USDEVCOM Army Research Laboratory · US

Funding

TRAINING FOR SPEECH AND HEARING SCIENCEST32DC000038 · NIDCD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Gwenaelle S Geleoc · 1992 to 2026
$21.8M
STRUCTURE/FUNCTION RELATIONS IN MIDDLE EARSR01DC000194 · NIDCD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ROSOWSKI, JOHN J · 1989 to 2018
$5.9M
NIDCD NIH HHS R01 DC000194NIDCD NIH HHS T32 DC000038
6 · The paper itself

Abstract

While many mouse models of hearing loss have been described, a significant fraction of the genetic defects in these models affect both the inner ear and middle ears. A common method used to separate inner-ear (sensory-neural) from middle-ear (conductive) pathologies in the hearing clinic is the combination of air-conduction and bone-conduction audiometry. In this report, we investigate the use of air- and bone-conducted evoked auditory brainstem responses to perform a similar separation in mice. We describe a technique by which we stimulate the mouse ear both acoustically and via whole-head vibration. We investigate the sensitivity of this technique to conductive hearing loss by introducing middle-ear lesions in normal hearing mice. We also use the technique to investigate the presence of an age-related conductive hearing loss in a common mouse model of presbycusis, the BALB/c mouse.

Indexed as

AccelerationAcoustic StimulationAgingAnimalsBone ConductionDisease Models, AnimalEvoked Potentials, Auditory, Brain StemHearing Loss, ConductiveHearing Loss, Mixed Conductive-SensorineuralMiceMice, Inbred BALB CMice, Inbred CBAPresbycusisSpecies SpecificityAir-bone gapAir conductionBone conductionPresbycusis

Identifiers

PMID28167132
PMCPMC5348262
OpenAlexW2585872332

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.