ArticleGastrointestinal endoscopy2017
Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus (with video).
Article in Gastrointestinal endoscopy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Optical Coherence Tomography Angiography of the Intestine: How to Prevent Motion Artifacts in Open and Laparoscopic Surgery?Life (Basel, Switzerland) · 2023Article
- En-face polarization-sensitive optical coherence tomography to characterize early-stage esophageal cancer and determine tumor margin.Biomedical optics express · 2022Article
- Endoscopic optical coherence tomography angiography using inverse SNR-amplitude decorrelation features and electrothermal micro-electro-mechanical system raster scan.Quantitative imaging in medicine and surgery · 2022Article
- Research progress on the application of optical coherence tomography in the field of oncology.Frontiers in oncology · 2022Review
- Quantitative analysis of vascular changes during photoimmunotherapy using speckle variance optical coherence tomography (SV-OCT).Biomedical optics express · 2021Article
- Advanced endoscopic imaging for detecting and guiding therapy of early neoplasias of the esophagus.Annals of the New York Academy of Sciences · 2020Review
- Biomedical optical imaging technology and applications: From basic research toward clinical diagnosis.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Optical Vaginal Biopsy Using Optical Coherence Tomography.Female pelvic medicine & reconstructive surgery · 2020Article
- Advances in Doppler optical coherence tomography and angiography.Translational biophotonics · 2019Article
- Comparison of optical coherence tomography angiography and narrow-band imaging using a bimodal endoscope.Journal of biomedical optics · 2019Article
- Volumetric laser endomicroscopy and optical coherence tomography in Barrett's esophagus: a systematic review and meta-analysis.Endoscopy international open · 2019Review
- Barrett's Esophagus and Esophageal Carcinoma: Can Biomarkers Guide Clinical Practice?Current gastroenterology reports · 2019Review
- Non-Invasive Quantification of the Growth of Cancer Cell Colonies by a Portable Optical Coherence Tomography.Micromachines · 2019Article
- Advanced Imaging for Barrett's Esophagus and Early Neoplasia: Surface and Subsurface Imaging for Diagnosis and Management.Current gastroenterology reports · 2018Review
- Biomarkers of Barrett's Esophagus: From the Laboratory to Clinical Practice.Digestive diseases and sciences · 2018Review
- Ultrahigh-speed endoscopic optical coherence tomography and angiography enables delineation of lateral margins of endoscopic mucosal resection: a case report.Therapeutic advances in gastroenterology · 2017Article
- Endoscopic optical coherence tomography: technologies and clinical applications [Invited].Biomedical optics express · 2017Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsAngiogenesis is associated with neoplastic progression of Barrett's esophagus (BE). Volumetric optical coherence tomography angiography (OCTA) visualizes subsurface microvasculature without exogenous contrast agents. We investigated the association of OCTA microvascular features with low-grade dysplasia (LGD) and high-grade dysplasia (HGD).
methodsFifty-two patients undergoing BE surveillance or endoscopic eradication therapies for dysplasia were imaged using volumetric OCTA and corresponding histologic diagnoses wre obtained to yield 97 data sets (nondysplastic BE [NDBE], 74; LGD, 10; HGD, 13). After evaluating OCTA image quality, 54 datasets (NDBE, 35; LGD, 8; HGD, 11) from 32 patients were used to develop a training and reading protocol. The association of abnormal vessel branching and heterogeneous vessel size with LGD/HGD and a regular honeycomb vessel pattern with NDBE were investigated.
resultsBlinded OCTA reading of 41 OCTA datasets (NDBE, 27; LGD, 7; HGD, 7) was performed by readers with various levels of OCT/OCTA experience including 3 OCT trainees, 1 gastroenterologist, and 2 gastroenterology fellows. Among the 6 readers, OCTA features of abnormal vessel branching and heterogeneous vessel size had an overall 94% sensitivity (95% CI, 89-99) and 69% specificity (95% CI, 62-76) for differentiating LGD/HGD versus NDBE with a mean reading time of 45 seconds per data set and moderate (kappa = .58) interobserver agreement.
conclusionsVolumetric en face OCTA imaging enables rapid examination of depth resolved microvascular features with near-microscopic resolution. OCTA can visualize microvascular features associated with LGD/HGD with high accuracy, which motivates new technologic advances and future studies investigating the diagnostic performance of OCTA.
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