ArticleeLife2017
Generation of shape complexity through tissue conflict resolution.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 87 citations in OpenAlex.
- Growth-rate coordination across the width of a leaf preserves its flatness.PLoS biology · 2026Article
- Discrete 2D Material Programming for 3D Shaping and Morphogenesis-Inspired 4D Bioprinting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Shaping of developmental gradients through selection on multiple loci inScience advances · 2026Article
- Growth history leaves a geometric trace in puzzle cells.EMBO reports · 2026Article
- Self-organization underlies developmental robustness in plants.Cells & development · 2025Review
- Evolution of petal patterning: blooming floral diversity at the microscale.The New phytologist · 2025Review
- The unique morphological basis and repeated evolutionary origins of personate flowers in Penstemon.American journal of botany · 2025Article
- Mechanical interactions between tissue layers underlie plant morphogenesis.Nature plants · 2025Article
- Arabidopsis floral buds are locked through stress-induced sepal tip curving.Nature plants · 2024Article
- Spatiotemporally distinct responses to mechanical forces shape the developing seed of Arabidopsis.The EMBO journal · 2024Article
- A CUC1/auxin genetic module links cell polarity to patterned tissue growth and leaf shape diversity in crucifer plants.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Inter-plane feedback coordinates cell morphogenesis and maintains 3D tissue organization in the Drosophila pupal retina.Development (Cambridge, England) · 2024Article
- Spatio-temporal expression of candidate genes for nectar spur development in Tropaeolum (Tropaeolaceae: Brassicales).Annals of botany · 2023Article
- The dynamics and biophysics of shape formation: Common themes in plant and animal morphogenesis.Developmental cell · 2023Review
- Computer models of cell polarity establishment in plants.Plant physiology · 2023Review
- Anisotropic cell growth at the leaf base promotes age-related changes in leaf shape in Arabidopsis thaliana.The Plant cell · 2023Article
- An optimized pipeline for live imaging whole Arabidopsis leaves at cellular resolution.Plant methods · 2023Article
- How Cell Geometry and Cellular Patterning Influence Tissue Stiffness.International journal of molecular sciences · 2022Article
- Pole position: How plant cells polarize along the axes.The Plant cell · 2022Review
- Testing candidate genes linked to corolla shape variation of a pollinator shift in Rhytidophyllum (Gesneriaceae).PloS one · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Out-of-plane tissue deformations are key morphogenetic events during plant and animal development that generate 3D shapes, such as flowers or limbs. However, the mechanisms by which spatiotemporal patterns of gene expression modify cellular behaviours to generate such deformations remain to be established. We use the Snapdragon flower as a model system to address this problem. Combining cellular analysis with tissue-level modelling, we show that an orthogonal pattern of growth orientations plays a key role in generating out-of-plane deformations. This growth pattern is most likely oriented by a polarity field, highlighted by PIN1 protein localisation, and is modulated by dorsoventral gene activity. The orthogonal growth pattern interacts with other patterns of differential growth to create tissue conflicts that shape the flower. Similar shape changes can be generated by contraction as well as growth, suggesting tissue conflict resolution provides a flexible morphogenetic mechanism for generating shape diversity in plants and animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.