Evidence map›Paper›PMID 28166818›Full record

ArticleMicrobiome2017

Resistant starch can improve insulin sensitivity independently of the gut microbiota.

Laure B Bindels, Rafael R Segura Munoz, João Carlos Gomes-Neto, Valentin Mutemberezi, Inés Martínez, Nuria Salazar, Elizabeth A Cody, Maria I Quintero-Villegas, Hatem Kittana, Clara G de Los Reyes-Gavilán and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 3 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 167 citations in OpenAlex.

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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Laure B BindelsDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Rafael R Segura MunozDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.
João Carlos Gomes-NetoDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Valentin MutembereziBioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Inés MartínezDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Nuria SalazarDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias-Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Asturias, Spain.
Elizabeth A CodyDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Maria I Quintero-VillegasDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Hatem KittanaDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Clara G de Los Reyes-GavilánDepartment of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias-Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Asturias, Spain.
Robert J SchmaltzDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Giulio G MuccioliBioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Jens WalterDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Amanda E Ramer-TaitDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA. aramer-tait2@unl.edu.
University of Nebraska–Lincoln · USUCLouvain · BEUniversity of Alberta · CAConsejo Superior de Investigaciones Científicas · ESInstituto de Productos Lácteos de Asturias · ES

Funding

The role of stress in the fetal origin of obesity and metabolic dysfunctionP20GM104320 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI ZEMPLENI, JANOS · 2014 to 2024
$24.9M
NIGMS NIH HHS P20 GM104320
6 · The paper itself

Abstract

backgroundObesity-related diseases, including type 2 diabetes and cardiovascular disease, have reached epidemic proportions in industrialized nations, and dietary interventions for their prevention are therefore important. Resistant starches (RS) improve insulin sensitivity in clinical trials, but the mechanisms underlying this health benefit remain poorly understood. Because RS fermentation by the gut microbiota results in the formation of physiologically active metabolites, we chose to specifically determine the role of the gut microbiota in mediating the metabolic benefits of RS. To achieve this goal, we determined the effects of RS when added to a Western diet on host metabolism in mice with and without a microbiota.

resultsRS feeding of conventionalized mice improved insulin sensitivity and redressed some of the Western diet-induced changes in microbiome composition. However, parallel experiments in germ-free littermates revealed that RS-mediated improvements in insulin levels also occurred in the absence of a microbiota. RS reduced gene expression of adipose tissue macrophage markers and altered cecal concentrations of several bile acids in both germ-free and conventionalized mice; these effects were strongly correlated with the metabolic benefits, providing a potential microbiota-independent mechanism to explain the physiological effects of RS.

conclusionsThis study demonstrated that some metabolic benefits exerted by dietary RS, especially improvements in insulin levels, occur independently of the microbiota and could involve alterations in the bile acid cycle and adipose tissue immune modulation. This work also sets a precedent for future mechanistic studies aimed at establishing the causative role of the gut microbiota in mediating the benefits of bioactive compounds and functional foods.

Indexed as

Insulin ResistanceAdipose TissueAnimalsBileDietary CarbohydratesDiet, WesternGastrointestinal MicrobiomeInsulinMacrophagesMiceStarchDietary CarbohydratesInsulinStarchAdipose tissue macrophagesGut microbiotaInsulin sensitivityResistant starch

Identifiers

PMID28166818
PMCPMC5294823
OpenAlexW2585111741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.