Evidence map›Paper›PMID 28166780›Full record

Trial reportNutrition journal2017

Effect of a high protein diet and/or resistance exercise on the preservation of fat free mass during weight loss in overweight and obese older adults: a randomized controlled trial.

Amely M Verreijen, Mariëlle F Engberink, Robert G Memelink, Suzanne E van der Plas, Marjolein Visser, Peter J M Weijs

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07457437 (Effect of a Progressive Resistance Exercise Program on Muscle Mass and Physical Function During a Tirzepatide Induced Weight Loss in Overweight and Obese Females), which is not on this map. Cited by 58 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 10 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07457437 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effect of a Progressive Resistance Exercise Program on Muscle Mass and Physical Function During a Tirzepatide Induced Weight Loss in Overweight and Obese Females: a Randomised Parallel Group Study

TypeinterventionalSponsorUniversity of ExeterRan2026 to 2027Enrolled60ConditionsMuscle Mass and Strength, Obesity & Overweight, Physical FunctionArmsProgressive Resistance Exercise Training Program, Habitual physical activity guidelines
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 10 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amely M VerreijenDepartment of Nutrition and Dietetics, Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Dr. Meurerlaan 8, 1067 SM, Amsterdam, Netherlands. a.verreijen@hva.nl.
Mariëlle F EngberinkDepartment of Nutrition and Dietetics, Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Dr. Meurerlaan 8, 1067 SM, Amsterdam, Netherlands.
Robert G MemelinkDepartment of Nutrition and Dietetics, Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Dr. Meurerlaan 8, 1067 SM, Amsterdam, Netherlands.
Suzanne E van der PlasDepartment of Nutrition and Dietetics, Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Dr. Meurerlaan 8, 1067 SM, Amsterdam, Netherlands.
Marjolein VisserDepartment of Health Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, De Boelenlaan 1085, 1081 HV, Amsterdam, Netherlands.
Peter J M WeijsDepartment of Nutrition and Dietetics, Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Dr. Meurerlaan 8, 1067 SM, Amsterdam, Netherlands.
Amsterdam University of Applied Sciences · NLAmsterdam UMC Location VUmc · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntentional weight loss in obese older adults is a risk factor for accelerated muscle mass loss. We investigated whether a high protein diet and/or resistance exercise preserves fat free mass (FFM) during weight loss in overweight and obese older adults.

methodsWe included 100 overweight and obese adults (55-80 year) in a randomized controlled trial (RCT) with a 2 × 2 factorial design and intention-to-treat analysis. During a 10-week weight loss program all subjects followed a hypocaloric diet. Subjects were randomly allocated to either a high protein (1.3 g/kg body weight) or normal protein diet (0.8 g/kg), with or without a resistance exercise program 3 times/week. FFM was assessed by air displacement plethysmography.

resultsAt baseline, mean (±SD) BMI was 32 ± 4 kg/m

conclusionA high protein diet, though lower than targeted, did not significantly affect changes in FFM during modest weight loss in older overweight and obese adults. There was no significant interaction between the high protein diet and resistance exercise for change in FFM. However, only the group with the combined intervention of high protein diet and resistance exercise significantly increased in FFM.

trial registrationDutch Trial Register, number NTR4556, date 05-01-2014.

Indexed as

Diet, High-ProteinResistance TrainingWeight LossAgedAged, 80 and overBody CompositionBody Mass IndexCaloric RestrictionDietary FatsDietary ProteinsDiet, ReducingFemaleHand StrengthHumansMaleMiddle AgedDietary FatsDietary ProteinsFat free massHigh protein dietObesityOlder adultsResistance exerciseWeight loss

Identifiers

PMID28166780
PMCPMC5294725
OpenAlexW2587159172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.