Evidence map›Paper›PMID 28166765›Full record

Trial reportBMC cancer2017

Optitrain: a randomised controlled exercise trial for women with breast cancer undergoing chemotherapy.

Y Wengström, K A Bolam, S Mijwel, C J Sundberg, M Backman, M Browall, J Norrbom, H Rundqvist

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02522260 (OptiTrain - Optimal Training for Women With Breast Cancer During Chemotherapy Treatment), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02522260 nacompletednot on this map

OptiTrain - Optimal Training for Women With Breast Cancer During Chemotherapy Treatment

TypeinterventionalSponsorKarolinska InstitutetRan2013 to 2021Enrolled240ConditionsWell BeingArmsResistance and aerobic training, Aerobic training, Standard supportive care
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Cardiovascular training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Pooled it
  4. Experiences of patients with metastatic colorectal cancer participating in a supervised exercise intervention during chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
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  20. Exercise Training for Cancer Survivors.Current treatment options in oncology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Y WengströmDepartment of Neurobiology, Care Science and Society, Division of Nursing, Karolinska Institutet, Karolinska University Hospital, 141 83 Huddinge, Stockholm, Sweden. yvonne.wengstrom@ki.se.
K A BolamÅstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Stockholm, Sweden.
S MijwelDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
C J SundbergDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
M BackmanDepartment of Neurobiology, Care Science and Society, Division of Nursing, Karolinska Institutet, Karolinska University Hospital, 141 83 Huddinge, Stockholm, Sweden.
M BrowallSchool of Health and Education, University of Skövde, Skövde, Sweden.
J NorrbomDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
H RundqvistDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEScience for Life Laboratory · SESwedish School of Sport and Health Sciences · SEUniversity of Skövde · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWomen with breast cancer undergoing chemotherapy suffer from a range of detrimental disease and treatment related side-effects. Exercise has shown to be able to counter some of these side-effects and improve physical function as well as quality of life. The primary aim of the study is to investigate and compare the effects of two different exercise regimens on the primary outcome cancer-related fatigue and the secondary outcomes muscle strength, function and structure, cardiovascular fitness, systemic inflammation, skeletal muscle gene activity, health related quality of life, pain, disease and treatment-related symptoms in women with breast cancer receiving chemotherapy. The second aim is to examine if any effects are sustained 1, 2, and 5 years following the completion of the intervention and to monitor return to work, recurrence and survival. The third aim of the study is to examine the effect of attendance and adherence rates on the effects of the exercise programme.

methodsThis study is a randomised controlled trial including 240 women with breast cancer receiving chemotherapy in Stockholm, Sweden. The participants are randomly allocated to either: group 1: Aerobic training, group 2: Combined resistance and aerobic training, or group 3: usual care (control group). During the 5-year follow-up period, participants in the exercise groups will receive a physical activity prescription. Measurements for endpoints will take place at baseline, after 16 weeks (end of intervention) as well as after 1, 2 and 5 years. DISCUSSION: This randomised controlled trial will generate substantial information regarding the effects of different types of exercise on the health of patients with breast cancer undergoing chemotherapy. We expect that dissemination of the knowledge gained from this study will contribute to developing effective long term strategies to improve the physical and psychosocial health of breast cancer survivors.

trial registrationOptiTrain - Optimal Training Women with Breast Cancer (OptiTrain), NCT02522260 ; Registration: June 9, 2015, Last updated version Feb 29, 2016. Retrospectively registered.

Indexed as

Exercise TherapyAdultAgedAntineoplastic AgentsBreast NeoplasmsCardiovascular SystemFemaleHumansMiddle AgedMuscle, SkeletalMuscle StrengthSwedenTreatment OutcomeYoung AdultAntineoplastic AgentsChemotherapyExercise interventionFatigueInflammationPatients with breast cancerSkeletal muscle

Identifiers

PMID28166765
PMCPMC5294772
OpenAlexW2586935276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.