ArticleBMC genomics2017
Prophages and adaptation of Staphylococcus aureus ST398 to the human clinic.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 54 citations in OpenAlex.
- A comprehensive review of regulatory mechanisms of novel enterotoxin genes inAnnals of medicine · 2026Review
- Molecular characteristics and pathogenicity-associated phenotypes of methicillin-resistantFrontiers in public health · 2026Article
- Effect of temperate bacteriophage vB_SauS_S1 on the adaptability and pathogenicity of Staphylococcus aureus ST398.BMC microbiology · 2025Article
- Directed evolution of bacteriophages: thwarted by prolific prophage.Applied and environmental microbiology · 2024Article
- Directed evolution of bacteriophages: impacts of prolific prophage.bioRxiv : the preprint server for biology · 2024Article
- The Role of Prophage ϕSa3 in the Adaption ofAntibiotics (Basel, Switzerland) · 2024Article
- Understanding the role ofFrontiers in medicine · 2024Review
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Article
- The analysis of the function, diversity, and evolution of the Bacillus phage genome.BMC microbiology · 2023Article
- Genome Analysis of Methicillin-Resistant and Methicillin-SusceptibleMicroorganisms · 2023Article
- The Role of Temperate Phages in Bacterial Pathogenicity.Microorganisms · 2023Review
- First comparative genomic characterization of the MSSA ST398 lineage detected in aquaculture and other reservoirs.Frontiers in microbiology · 2023Article
- Strong Biofilm Formation and Low Cloxacillin Susceptibility in Biofilm-Growing CC398Microorganisms · 2022Article
- Phage Therapy againstPharmaceutics · 2022Article
- A One Health Approach Molecular Analysis ofAntibiotics (Basel, Switzerland) · 2022Article
- The Prevalence and Molecular Biology ofAntibiotics (Basel, Switzerland) · 2022Article
- Analysis of intact prophages in genomes ofFrontiers in microbiology · 2022Article
- TheGenes · 2021Review
- Comparative analysis of prophages carried by human and animal-associated Staphylococcus aureus strains spreading across the European regions.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been suggested that prophages in the ST398 S. aureus clone are responsible for expanding ST398's spectrum of action and increasing its ability to cause human infections. We carried out the first characterization of the various prophages carried by 76 ST398 bloodstream infection (BSI) isolates obtained over 9 years of observation.
resultsWhole-genome sequencing of 22 representative isolates showed (1) the presence of the φ3-prophage and diverse genetic features typical of animal-associated isolates (i.e., SCCmec XI element, Tn916 transposon and non φ3-prophages) in a majority of BSI isolates, (2) one BSI isolate devoid of the φ3-prophage but otherwise similar to an animal-infecting isolate, (3) 35 prophages carrying numerous genes previously associated with virulence or immune evasion in animal models of staphylococcal infections. The analysis of prophage content in all 76 BSI isolates showed an increasing prevalence of polylysogeny over time. Overall, over the course of the last 10 years, the BSI isolates appear to have acquired increasing numbers of genetic features previously shown to contribute to bacterial adaptation and virulence in animal models of staphylococcal infections.
conclusionsWe hypothesize that lysogeny has played a significant role in increasing the ability of the ST398 clone to cause infections in humans. Our findings highlight the risk that the ST398 lineage will increase its threat to public health by continuing to acquire virulence and/or multiple antibiotic-resistance genes from hospital-associated clones of Staphylococcus aureus.
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