ArticlePloS one2017
Identification of shared risk loci and pathways for bipolar disorder and schizophrenia.
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Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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44citing papers in PubMed, 1 pooled it
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.Nature genetics · 2021Pooled it
- Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.JAMA psychiatry · 2018Trial
- Uncovering causal associations between plasma proteins and psychiatric disorders and identifying comorbidity biomarkers: a mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Beyond DSM Categories: Criteria for Biologically Valid Disease Axes in Psychiatry.Journal of clinical medicine · 2026Review
- Shared and Distinct Time-Space Experiences Along the Psychotic-Affective Continuum.Schizophrenia bulletin · 2026Article
- Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes.Schizophrenia bulletin · 2026Article
- Polyunsaturated fatty acids and psychotic disorders: integrating mechanistic, genetic, and clinical evidence.Frontiers in nutrition · 2026Review
- Toll-like receptor 3 (TLR 3) polymorphisms predisposition to schizophrenia and bipolar disorder.Molecular biology reports · 2025Article
- Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes.Scientific reports · 2025Article
- TLR4 Polymorphisms (T399I/D299G) Association with Schizophrenia and Bipolar Disorder in a Tunisian Population.Biochemical genetics · 2024Article
- Excitatory Dysfunction Drives Network and Calcium Handling Deficits in 16p11.2 Duplication Schizophrenia Induced Pluripotent Stem Cell-Derived Neurons.Biological psychiatry · 2023Article
- Epigenetic age deacceleration in youth at familial risk for schizophrenia and bipolar disorder.Translational psychiatry · 2023Article
- Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of immature neutrophil cells with association to lipid changes.Translational psychiatry · 2023Article
- Interactive effects of polygenic risk and cognitive subtype on brain morphology in schizophrenia spectrum and bipolar disorders.European archives of psychiatry and clinical neuroscience · 2022Article
- Patterns of Convergence and Divergence Between Bipolar Disorder Type I and Type II: Evidence From Integrative Genomic Analyses.Frontiers in cell and developmental biology · 2022Article
- Novel loci and potential mechanisms of major depressive disorder, bipolar disorder, and schizophrenia.Science China. Life sciences · 2022Article
- Genome-wide association study accounting for anticholinergic burden to examine cognitive dysfunction in psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Mood Stabilizers in Psychiatric Disorders and Mechanisms Learnt from In Vitro Model Systems.International journal of molecular sciences · 2021Review
- Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.Molecular psychiatry · 2021Article
- Genetic variants in the bipolar disorder risk locus SYNE1 that affect CPG2 expression and protein function.Molecular psychiatry · 2021Article
Corrections and comments
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Authors and funding
69 authors at 20 institutions in 12 countries.
Andreas J ForstnerInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Julian HeckerInstitute for Genomics Mathematics, University of Bonn, Bonn, Germany.
Andrea HofmannInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Anna MaaserInstitute of Human Genetics, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-9440-0712
Céline S ReinboldHuman Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-3394-3158
Thomas W MühleisenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Markus LeberDepartment of Psychiatry & Psychotherapy, University of Cologne, Cologne, Germany.
Jana StrohmaierDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany.
Franziska DegenhardtInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Jens TreutleinDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany.
Manuel MattheisenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Johannes SchumacherInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0003-1080-4339
Sandra MeierDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany.
Stefan HermsInstitute of Human Genetics, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-2786-8200
Per HoffmannInstitute of Human Genetics, University of Bonn, Bonn, Germany.
André LacourGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-1571-1468
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany.
Bertram Müller-MyhsokMax Planck Institute of Psychiatry, Munich, Germany.
Susanne LucaeMax Planck Institute of Psychiatry, Munich, Germany.
Wolfgang MaierDepartment of Psychiatry, University of Bonn, Bonn, Germany.
Markus SchwarzPsychiatric Center Nordbaden, Wiesloch, Germany.
Helmut VedderPsychiatric Center Nordbaden, Wiesloch, Germany.
Jutta Kammerer-CierniochCenter of Psychiatry Weinsberg, Weinsberg, Germany.
Andrea PfennigDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.
Michael BauerDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.
Martin HautzingerDepartment of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, Tübingen, Germany.
Susanne MoebusInstitute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany.
Lorena M SchenkInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Sascha B FischerHuman Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-0336-0784
Sugirthan SivalingamInstitute of Human Genetics, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-5239-5137
Piotr M CzerskiLaboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Joanna HauserLaboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.ORCID http://orcid.org/0000-0002-6621-3493
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology Warsaw, Warsaw, Poland.
Neonila Szeszenia-DabrowskaDepartment of Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Paul BrennanGenetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France.
James D McKayGenetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon, France.
Adam WrightSchool of Psychiatry, University of New South Wales, Randwick, Australia.
Philip B MitchellSchool of Psychiatry, University of New South Wales, Randwick, Australia.ORCID http://orcid.org/0000-0002-7954-5235
Janice M FullertonNeuroscience Research Australia, Sydney, Australia.
Peter R SchofieldNeuroscience Research Australia, Sydney, Australia.ORCID http://orcid.org/0000-0003-2967-9662
Grant W MontgomeryQueensland Institute of Medical Research (QIMR), Brisbane, Australia.
Sarah E MedlandQueensland Institute of Medical Research (QIMR), Brisbane, Australia.
Scott D GordonQueensland Institute of Medical Research (QIMR), Brisbane, Australia.ORCID http://orcid.org/0000-0001-7623-328X
Nicholas G MartinQueensland Institute of Medical Research (QIMR), Brisbane, Australia.
Valery KrasnovMoscow Research Institute of Psychiatry, Moscow, Russian Federation.
Alexander ChuchalinInstitute of Pulmonology, Russian State Medical University, Moscow, Russian Federation.
Gulja BabadjanovaInstitute of Pulmonology, Russian State Medical University, Moscow, Russian Federation.
Galina PantelejevaRussian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation.
Lilia I AbramovaRussian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation.
Alexander S TiganovRussian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation.
Alexey PolonikovDepartment of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation.
Elza KhusnutdinovaInstitute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russian Federation.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, Canada.ORCID http://orcid.org/0000-0001-9544-3944
Cristiana CruceanuMontreal Neurological Institute, McGill University, Montreal, Canada.ORCID http://orcid.org/0000-0002-7799-5531
Guy A RouleauMontreal Neurological Institute, McGill University, Montreal, Canada.
Gustavo TureckiDepartment of Human Genetics, McGill University, Montreal, Canada.
Catherine LapriseDépartement des sciences fondamentales, Université du Québec à Chicoutimi (UQAC), Saguenay, Canada.
Fabio RivasDepartment of Psychiatry, Hospital Regional Universitario, Biomedical Institute of Malaga, Malaga, Spain.
Fermin MayoralDepartment of Psychiatry, Hospital Regional Universitario, Biomedical Institute of Malaga, Malaga, Spain.ORCID http://orcid.org/0000-0002-9710-9672
Manolis KogevinasCenter for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Maria Grigoroiu-SerbanescuBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Tim BeckerGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Thomas G SchulzeInstitute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-5236-6149
Sven CichonInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Heide FierInstitute for Genomics Mathematics, University of Bonn, Bonn, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
University of Bonn · DEHeidelberg University · DEQIMR Berghofer Medical Research Institute · AUMental Health Research Center of Russian Academy of Medical Sciences · RUBlack Dog Institute · AUCentre international de recherche sur le cancer · FRHospital Regional Universitario de Málaga · ESMontreal Neurological Institute and Hospital · CAPirogov Russian National Research Medical University · RUPoznan University of Medical Sciences · PLUniversity Hospital Carl Gustav Carus · DEUniversity of Basel · CHUNSW Sydney · AUAarhus University · DKCenter for Research in Environmental Epidemiology · ESDalhousie University · CADouglas Mental Health University Institute · CAGerman Center for Neurodegenerative Diseases · DEGoethe University Frankfurt · DEKursk State Medical University · RU
Funding
Wellcome TrustWorld Health Organization 001
Abstract
Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (p = 1.46x10-8). This provides further evidence that SCZ-associated loci contribute to the development of BD. Two SNPs remained significant after Bonferroni correction. The most strongly associated SNP was located near TRANK1, which is a reported genome-wide significant risk gene for BD. Pathway analyses for all shared SCZ-BD SNPs revealed 25 nominally enriched gene-sets, which showed partial overlap in terms of the underlying genes. The enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. The present data provide further insights into shared risk loci and disease-associated pathways for BD and SCZ. This may suggest new research directions for the treatment and prevention of these two major psychiatric disorders.
Indexed as
Genetic Predisposition to DiseaseQuantitative Trait LociSignal TransductionBipolar DisorderGenetic LinkageGenome-Wide Association StudyHumansLinkage DisequilibriumPolymorphism, Single NucleotideRiskSchizophrenia
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