ArticlePloS one2017
Medication-related factors associated with health-related quality of life in patients older than 65 years with polypharmacy.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03689049 (SPIDER), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SPIDER: A Structured Process Informed by Data, Evidence and Research - A Research and Quality Improvement Collaboration Supporting Practices in Improving Care for Complex Elderly Patients
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Prevalence and impact of polypharmacy in older patients with type 2 diabetes.Aging clinical and experimental research · 2022Pooled it
- Development of a model of medication review for use in clinical practice: Bristol medication review model.BMC medicine · 2021Pooled it
- Polypharmacy and health outcomes in atrial fibrillation: a systematic review and meta-analysis.Open heart · 2020Pooled it
- Health-related quality of life among older adults following acute hospitalization: longitudinal analysis of a randomized controlled trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Trial
- Trial
- Baseline Prevalence of Polypharmacy in Older Hypertensive Study Subjects with Elevated Dementia Risk: Findings from the Risk Reduction for Alzheimer's Disease Study (rrAD).Journal of Alzheimer's disease : JAD · 2020Trial
- Associations Between Polypharmacy, Symptom Burden, and Quality of Life in Patients with Advanced, Life-Limiting Illness.Journal of general internal medicine · 2019Trial
- Trial
- Impact of structured medication reviews on prescribing in English primary care: a retrospective observational cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Observational
- Exploration of Polyhydroxybutyrate (PHB) Production Potential of Photosynthetic Microbes: A Sustainable Source of Bioplastic.Recent patents on biotechnology · 2026Article
- Perspective of older people on which medicines they need to report to healthcare professionals as part of a medicines history: a qualitative descriptive study.International journal of clinical pharmacy · 2025Article
- Potentially inappropriate medication use and comorbidity in association with quality of life in community-dwelling older people: a cross-sectional study in Iran.BMC primary care · 2025Article
- Experience of the Burden of Using Multiple Medicines and the Associated Impact on Health-Related Quality of Life.Journal of patient experience · 2025Article
- The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy.European geriatric medicine · 2024Article
- Stakeholders' perspectives about challenges, strategies and outcomes of importance associated with adherence to appropriate polypharmacy in older patients - A qualitative study.Exploratory research in clinical and social pharmacy · 2024Article
- Polypharmacy and the Change of Self-Rated Health in Community-Dwelling Older Adults.International journal of environmental research and public health · 2023Article
- Assessment of Drug-Related Problems and Health-Related Quality of Life Domains in Elderly Patients with Type 2 Diabetes Mellitus.Therapeutics and clinical risk management · 2023Article
- Polypharmacy and trajectories of health-related quality of life in older adults: an Australian cohort study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Polypharmacy and Health-Related Quality of Life/Psychological Distress Among Patients With Chronic Disease.Preventing chronic disease · 2022Article
- Ageing well with diabetes: A workshop to co-design research recommendations for improving the diabetes care of older people.Diabetic medicine : a journal of the British Diabetic Association · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
METHODS AND
designObjective: To describe the relationship between medication-related factors and the health-related quality of life in patients older than 65 years who use multiple medications (polypharmacy). Design: Cross-sectional descriptive study. Setting: Primary care. Participants: Patients older than 65 years who use multiple medications (n = 375). Measurements: The main outcome measure was health-related quality of life according to the EuroQol-5D instrument. Sociodemographic, clinical and medication-related variables were recorded during home interviews.
resultsMean age was 74.72 ± 5.59 years, and 65.5% of our participants were women. The global level of health-related quality of life according to the EQ-5D visual analog scale was 59.25 ± 20.92. Of the five EuroQol dimensions, anxiety/depression and pain were the most frequently reported, while mobility and self-care were the dimensions with the greatest impact on self-reported quality of life. Multivariate analysis indicated that functional independence was the factor most strongly associated (β = 14.27 p < 0.001) with better health-related quality of life, while illiteracy (β = -13.58 p < 0.001), depression (β = -10.13 p < 0.001), social risk (β = -7.23 p = 0.004) and using more than 10 medicines (β = -4.85 p = 0.009) were strongly associated with a poorer health-related quality of life.
conclusionsFactors inherent within the patient such as functional incapacity, cognitive impairment and social and emotional problems were the main constraints to quality of life in our study population. The number of medicines taken was negatively related with quality of life.
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