ArticleNature genetics2017
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 238 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
238citing papers in PubMed, 5 pooled it
43.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
238 citing papers in PubMed, 5 syntheses or guidelines pooled it, 433 citations in OpenAlex.
- Pooled it
- Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD.Respiratory research · 2021Pooled it
- A Prospective Analysis of Genetic Variants Associated with Human Lifespan.G3 (Bethesda, Md.) · 2019Pooled it
- Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis.Environmental health perspectives · 2019Pooled it
- Systematic Review and Meta-Analysis Confirms Significant Contribution of Surfactant Protein D in Chronic Obstructive Pulmonary Disease.Frontiers in genetics · 2019Pooled it
- Gene network approach reveals co-expression patterns in nasal and bronchial epithelium.Scientific reports · 2019Trial
- DSP variants may be associated with longitudinal change in quantitative emphysema.Respiratory research · 2019Trial
- Genome-Wide Association Analysis of Single-Breath DlAmerican journal of respiratory cell and molecular biology · 2019Trial
- Multi-omics study to elucidate molecular mechanism of polyhexamethylene guanidine phosphate (PHMG-p)-induced pulmonary damage in mice.Archives of toxicology · 2026Article
- Desmoplakin loss in alveolar epithelium drives Wnt/β-Catenin-mediated extracellular matrix remodeling and fibrotic signaling in vitro.Molecular biology reports · 2026Article
- PER1-related inflammatory signaling links night shift exposure to lower lung function in coal miners.iScience · 2026Article
- Integrative Multivariate Genomics Identifies Shared Epithelial-Immune and Cytokine-Regulatory Mechanisms Across Major Chronic Lung Diseases.International journal of molecular sciences · 2026Article
- Defective alveolar regeneration in emphysema: identifying dysfunctional cellular crosstalk and novel therapeutic opportunities for tissue repair.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease.Physiological reviews · 2026Review
- Long isoforms of the COPD risk gene FAM13A orchestrate human lung epithelial development.American journal of respiratory cell and molecular biology · 2026Article
- Joint Associations of Sleep Patterns and Genetic Susceptibility With Dynamic Transitions of Chronic Obstructive Pulmonary Disease and Coronary Heart Disease and the Mediating Role of Inflammatory Biomarkers and Metabolites.Journal of the American Heart Association · 2026Article
- Coronary artery disease risk gene PRDM16 regulates smooth muscle homeostasis.Journal of molecular and cellular cardiology · 2026Article
- TP53/TAU axis regulates microtubule bundling to control alveolar stem cell-mediated regeneration.The Journal of clinical investigation · 2026Article
- Single-cell lung eQTL dataset of Asian never-smokers highlights the roles of alveolar cells in lung cancer etiology.bioRxiv : the preprint server for biology · 2026Article
- Tonsillar expression quantitative trait loci verify and expand genetic contributors to childhood atopic diseases.bioRxiv : the preprint server for biology · 2026Article
178 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
83 authors at 20 institutions in 7 countries.
Brian D HobbsChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0001-9564-0745
Kim de JongUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.
Maxime LamontagneInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.
Yohan BosséInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.ORCID http://orcid.org/0000-0002-3067-3711
Nick ShrineGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.
María Soler ArtigasGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.
Louise V WainGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0003-4951-1867
Ian P HallDivision of Respiratory Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Victoria E JacksonGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.
Annah B WyssEpidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA.ORCID http://orcid.org/0000-0003-4911-5290
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
David P StrachanPopulation Health Research Institute, St George's, University of London, London, UK.ORCID http://orcid.org/0000-0001-7854-1366
Terri H BeatyJohns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
John E HokansonDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
James D CrapoDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colorado, USA.
Peter J CastaldiChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Robert P ChaseChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Traci M BartzCardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.
Susan R HeckbertCardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.
Bruce M PsatyCardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.
Sina A GharibComputational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Department of Medicine, University of Washington, Seattle, Washington, USA.
Pieter ZanenDepartment of Pulmonology, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.
Jan W LammersDepartment of Pulmonology, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.
Matthijs OudkerkUniversity of Groningen, University Medical Center Groningen, Center for Medical Imaging, Groningen, the Netherlands.
H J GroenUniversity of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, the Netherlands.
Nicholas LocantoreGSK R&D, King of Prussia, Pennsylvania, USA.
Ruth Tal-SingerGSK R&D, King of Prussia, Pennsylvania, USA.
Stephen I RennardPulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Jørgen VestboSchool of Biological Sciences, University of Manchester, Manchester, UK.
Wim TimensDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-4146-6363
Peter D ParéUniversity of British Columbia Center for Heart Lung Innovation and Institute for Heart and Lung Health, St Paul's Hospital, Vancouver, British Columbia, Canada.
Jeanne C LatourelleDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
George T O'ConnorNational Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.
Jemma B WilkNational Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.
Woo Jin KimDepartment of Internal Medicine and Environmental Health Center, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Mi Kyeong LeeDepartment of Internal Medicine and Environmental Health Center, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Yeon-Mok OhDepartment of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Judith M VonkUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.
Harry J de KoningDepartment of Public Health, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.
Shuguang LengLovelace Respiratory Research Institute, Albuquerque, New Mexico, USA.
Steven A BelinskyLovelace Respiratory Research Institute, Albuquerque, New Mexico, USA.
Yohannes TesfaigziLovelace Respiratory Research Institute, Albuquerque, New Mexico, USA.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
Xin-Qun WangDepartment of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
R Graham BarrDepartment of Medicine, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
David SparrowVA Boston Healthcare System and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Augusto A LitonjuaChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Per BakkeDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Amund GulsvikDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Lies LahousseDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-3494-4363
Guy G BrusselleDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Bruno H StrickerDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
André G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Elizabeth J AmplefordCenter for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Eugene R BleeckerCenter for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Prescott G WoodruffCardiovascular Research Institute and Department of Medicine, Division of Pulmonary, Critical Care, Sleep, and Allergy, University of California at San Francisco, San Francisco, California, USA.
Deborah A MeyersCenter for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Dandi QiaoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
David A LomasUniversity College London, London, UK.
Jae-Joon YimDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Deog Kyeom KimSeoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.
Iwona Hawrylkiewicz2nd Department of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
Pawel Sliwinski2nd Department of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
Megan HardinChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Tasha E FingerlinCenter for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA.
David A SchwartzCenter for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA.
Dirkje S PostmaUniversity of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands.
William MacNeeUniversity of Edinburgh, Edinburgh, UK.
Martin D TobinGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0002-3596-7874
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
H Marike BoezenUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-4907-1657
COPDGene Investigators
ECLIPSE Investigators
LifeLines Investigators
SPIROMICS Research Group
International COPD Genetics Network Investigators
UK BiLEVE Investigators
International COPD Genetics Consortium
Brigham and Women's Hospital · USUniversity Medical Center Groningen · NLBoston University · USUniversity of Leicester · GBAstraZeneca (United Kingdom) · GBGroup Health Cooperative · USLovelace Respiratory Research Institute · USSeoul National University · KRUniversity of North Carolina at Chapel Hill · USUniversity of Bergen · NOGhent University Hospital · BEInstitut universitaire de cardiologie et de pneumologie de Québec · CAJohns Hopkins University · USUniversity of British Columbia · CAUniversity of Edinburgh · GBUtrecht University · NLDutch Health Care Inspectorate · NLErasmus MC · NLNational Heart Lung and Blood Institute · USNational Institute of Environmental Health Sciences · US
Funding
WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1MGenetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MMetabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MRespiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, MARY E · 2013 to 2025
$24.9MMechanisms of Familial Pulmonary FibrosisP01HL092870 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SCHWARTZ, DAVID ALBERT · 2010 to 2020
$21.6MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MPulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2MRole of Genetics in Idiopathic Pulmonary Fibrosis (IPF)R01HL097163 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FINGERLIN, TASHA E., SCHWARTZ, DAVID ALBERT · 2009 to 2018
$16.4MSYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASEST32HL007427 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAWN L DEMEO, Edwin K Silverman · 1985 to 2026
$13.6MMedical Research Council G0902313Medical Research Council G1000861Medical Research Council MC_PC_12010Medical Research Council MR/N011317/1Medical Research Council MR/N024842/1NCI NIH HHS P30 CA118100NHLBI NIH HHS K01 HL129039NHLBI NIH HHS K08 HL097029NHLBI NIH HHS P01 HL092870NHLBI NIH HHS P01 HL105339NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R01 HL075478NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL084323NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL097163NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL113264NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL124233NHLBI NIH HHS R01 HL126596NHLBI NIH HHS R33 HL120770NHLBI NIH HHS T32 HL007427NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U01 HL137880NIH HHS S10 OD018526Wellcome Trust 202849/Z/16/Z
Abstract
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10
Indexed as
AdultAgedAged, 80 and overAllelesAsthmaFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLungMaleMiddle AgedPhenotypePolymorphism, Single NucleotidePulmonary Disease, Chronic Obstructive
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.