ArticleNature genetics2017
Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility.
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Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
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79citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
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Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Sex-specific analysis in Behçet's disease reveals higher genetic risk in male patients.Journal of autoimmunity · 2022Pooled it
- Article
- Behçet's spectrum disorders: genetic and immunological insights into an emerging disease concept.World journal of pediatrics : WJP · 2026Review
- HLA-B*51 Beyond Behcet's Disease: Topography of Symptoms, Associated Diagnoses, and Characterization of Chronic Inflammatory Arthritis Phenotypes.International journal of molecular sciences · 2026Article
- Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A conserved editing mechanism for the fidelity of bacterial cell wall biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Predicting response to infliximab and interferon-α in Behçet's syndrome: An exploratory analysis from the BIO-BEHÇET'S randomized controlled trial.Rheumatology and immunology research · 2025Article
- Crohn's Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function.Nature communications · 2025Article
- ImmunoMet Oncogenesis: A New Concept to Understand the Molecular Drivers of Cancer.Journal of clinical medicine · 2025Review
- Genetic predisposition to Behcet's disease mediated by a IL10RA enhancer polymorphism.Heliyon · 2025Article
- The research progress of LACC1.Frontiers in immunology · 2025Review
- The Possible Genetic and Environmental Factors Related to Behçet's Disease: Trisomy 8 and SARS-CoV-2.Internal medicine (Tokyo, Japan) · 2025Article
- Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Decoding Behcet's Uveitis: an In-depth review of pathogenesis and therapeutic advances.Journal of neuroinflammation · 2024Review
- Loss of developmentally derived Irf8+ macrophages promotes hyperinnervation and arrhythmia in the adult zebrafish heart.bioRxiv : the preprint server for biology · 2024Article
- Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome.The EMBO journal · 2023Article
- Functions of the RIP kinase family members in the skin.Cellular and molecular life sciences : CMLS · 2023Review
- Clinical trait-specific genetic analysis in Behçet's disease identifies novel loci associated with ocular and neurological involvement.Clinical immunology (Orlando, Fla.) · 2023Article
- EULAR study group on 'MHC-I-opathy': identifying disease-overarching mechanisms across disciplines and borders.Annals of the rheumatic diseases · 2023Review
- Recent advances in the development of RIPK2 modulators for the treatment of inflammatory diseases.Frontiers in pharmacology · 2023Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 8 institutions in 5 countries.
Masaki TakeuchiInflammatory Disease Section, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Nobuhisa MizukiDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Akira MeguroDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Michael J OmbrelloTranslational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, US National Institutes of Health, Bethesda, Maryland, USA.
Yohei KirinoDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Colleen SatoriusInflammatory Disease Section, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Julie LeInflammatory Disease Section, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Mary BlakeTranslational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, US National Institutes of Health, Bethesda, Maryland, USA.
Burak ErerInflammatory Disease Section, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Tatsukata KawagoeDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Duran UstekDepartment of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey.
Ilknur Tugal-TutkunDepartment of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Emire SeyahiDepartment of Internal Medicine, Division of Rheumatology, Cerrahpasş a Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Yilmaz OzyazganDepartment of Ophthalmology, Cerrahpaşa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Inês SousaInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Fereydoun DavatchiRheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Vânia FranciscoInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Farhad ShahramRheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Bahar Sadeghi AbdollahiRheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Abdolhadi NadjiRheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Niloofar Mojarad ShafieeRheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Fahmida GhaderibarmiRheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Shigeaki OhnoDepartment of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Atsuhisa UedaDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yoshiaki IshigatsuboDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Massimo GadinaTranslational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, US National Institutes of Health, Bethesda, Maryland, USA.
Sofia A OliveiraInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Ahmet GülDepartment of Internal Medicine, Division of Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Daniel L KastnerInflammatory Disease Section, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Elaine F RemmersInflammatory Disease Section, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
National Institutes of Health · USTehran University of Medical Sciences · IRIstanbul University · TRYokohama City University · JPUniversity of Lisbon · PTHokkaido University · JPIstanbul University-Cerrahpaşa · TRNational Human Genome Research Institute · US
Funding
Translational Immunology research: a support for clinical immunological researchZICAR041181 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GADINA, MASSIMO · 2009 to 2025
$31.5MGenetics and pathophysiology of systemic juvenile idiopathic arthritis and other complex autoinflammatory diseasesZIAAR041198 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI OMBRELLO, MICHAEL · 2014 to 2025
$14.4MGenetics, Natural History, and Pathophysiology of Behcet's DiseaseZIAHG200374 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI KASTNER, DANIEL · 2011 to 2020
$10.5MGenetics Of Familial Mediterranean Fever/ Related ConditZ01AR041083 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KASTNER, DANIEL L · 1990 to 2008
$3.3MIntramural NIH HHS Z01 AR041083Intramural NIH HHS Z99 AR999999Intramural NIH HHS Z99 HG999999
Abstract
We analyzed 1,900 Turkish Behçet's disease cases and 1,779 controls genotyped with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for HLA-B*51. In the Turkish discovery set, we identified three new risk loci, IL1A-IL1B, IRF8, and CEBPB-PTPN1, with genome-wide significance (P < 5 × 10
Indexed as
AdultAllelesBehcet SyndromeCase-Control StudiesFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansIranMalePolymorphism, Single NucleotideTurkey
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