ArticlePlant signaling & behavior2017
Why do plants need so many cyclin-dependent kinase inhibitors?
Article in Plant signaling & behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Cyclin' Through the Root: Developmental Control of Cell Cycle Progression in theAnnual review of cell and developmental biology · 2026Review
- Genome-wide cyclin gene evolution in Arabidopsis and Brassica reveals polyploidization-driven duplication and flowering-time associations.Molecular genetics and genomics : MGG · 2026Article
- Thyme Oil Alleviates Cadmium-Induced Disturbances in Mitotic Activity, Cytoskeletal Organization and H3T3/H3S10 Phosphorylation inInternational journal of molecular sciences · 2026Article
- Cell cycle in plant development and reprogramming.Development (Cambridge, England) · 2026Review
- Dynamics of small RNAs in a red-fruited wine grape cultivar infected with Grapevine red blotch virus.BMC genomics · 2025Article
- Folate depletion impact on the cell cycle results in restricted primary root growth in Arabidopsis.Plant molecular biology · 2025Article
- Differential ABA sensitivity of superior and inferior rice grains is linked to cell cycle entry into endoreduplication.Frontiers in plant science · 2025Article
- What Is a Plant Cell Type in the Age of Single-Cell Biology? It's Complicated.Annual review of cell and developmental biology · 2024Review
- Zeocin-induced DNA damage response in barley and its dependence on ATR.Scientific reports · 2024Article
- The SIAMESE family of cell-cycle inhibitors in the response of plants to environmental stresses.Frontiers in plant science · 2024Review
- The response of Arabidopsis to the apocarotenoid β-cyclocitric acid reveals a role for SIAMESE-RELATED 5 in root development and drought tolerance.PNAS nexus · 2023Article
- AGAMOUS regulates various target genes via cell cycle-coupled H3K27me3 dilution in floral meristems and stamens.The Plant cell · 2023Article
- Characterization of the soybean KRP gene family reveals a key role for GmKRP2a in root development.Frontiers in plant science · 2023Article
- Members of SIAMESE-RELATED Class Inhibitor Proteins of Cyclin-Dependent Kinase Retard G2 Progression and Increase Cell Size inLife (Basel, Switzerland) · 2022Article
- Deceleration of the cell cycle underpins a switch from proliferative to terminal divisions in plant stomatal lineage.Developmental cell · 2022Article
- Connections between the Cell Cycle and the DNA Damage Response in Plants.International journal of molecular sciences · 2021Review
- Plant CDKs-Driving the Cell Cycle through Climate Change.Plants (Basel, Switzerland) · 2021Review
- Suppressor of Gamma Response 1 Modulates the DNA Damage Response and Oxidative Stress Response in Leaves of Cadmium-ExposedFrontiers in plant science · 2020Article
- Functional Analysis of Short Linear Motifs in the Plant Cyclin-Dependent Kinase Inhibitor SIAMESE.Plant physiology · 2018Article
- SIAMESE-RELATED1 Is Regulated Posttranslationally and Participates in Repression of Leaf Growth under Moderate Drought.Plant physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell cycle regulation is fundamental to growth and development, and Cyclin-Dependent Kinase Inhibitors (CKIs) are major negative regulators of the cell cycle. Plant genomes encode substantially more CKIs than metazoan or fungal genomes. Plant CKIs fall into 2 distinct families, KIP-RELATED PROTEINS (KRPs) and SIAMESE-RELATED proteins (SMRs). SMRs can inhibit both S-phase and M-phase CDK complexes in vitro and are transcribed throughout the cell cycle, yet SMRs do not inhibit DNA replication in vivo. This suggests that SMRs must be activated post transcriptionally after the start of S-phase, but the mechanism of this hypothesized activation is unknown. Recent work indicates that even distantly related SMRs have the same biochemical function, and that differential transcriptional regulation likely maintains their distinct roles in integrating various environmental and developmental signals with the cell cycle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.